摘要
目的研究注意力缺陷多动障碍儿童(attention deficit hyperactivity disorder,ADHD)事件相关电位(event related potential,ERP)的特征,研究ERP与多动指数及智力的相关性,探讨ADHD儿童的认知功能.方法选取2019年6月至2020年12月在厦门市仙岳医院门诊就诊的61例ADHD儿童作为研究组,选取符合纳入及排除标准的61名健康儿童作为对照组,行ERP及韦氏智力检查,对两组儿童照顾者行Conners父母问卷(PSQ)检查.结果在靶刺激下,研究组前额区、中央区、顶叶区的P3潜伏期明显长于对照组,差异均有统计学意义[(388.41±47.24)ms比(372.89±34.75)ms、(395.31±55.18)ms比(371.33±38.80)ms、(404.23±55.21)ms比(381.54±38.93)ms,t=2.07、2.78、2.62,均P<0.05];在靶刺激下,两组在前额区、中央区、顶叶区的P3波幅比较,差异均有统计学意义[9.61(7.60,15.63)μV比13.52(10.04,16.90)μV、11.20(5.81,17.43)μV比13.49(9.22,16.54)μV、12.33(7.05,18.85)μV比14.74(9.31,20.09)μV,Z=-2.77、-2.10、-2.06,均P<0.05].两组智力测验中的言语理解指数、知觉推理指数、工作记忆指数、加工速度指数及总智商得分比较,研究组均低于对照组,差异有统计学意义[98.0(89.0,103.5)比99.0(95.5,107.0)、94.0(86.0,103.0)比100.0(89.0,109.0)、85.0(75.0,97.0)比91.0(87.0,97.0)、83.0(77.0,95.0)比92.0(80.5,99.0)、83.0(77.0,95.0)比92.0(80.5,99.0),Z=-2.10、-2.54、-3.70、-3.33、-2.86,均P<0.05];研究组的多动指数评分高于对照组[1.80(1.60,2.10)比0.80(0.65,1.15),Z=-9.54,P<0.05].相关分析结果显示,研究组的P3潜伏期与工作记忆指数(WMI)和加工速度指数(PSI)呈负相关(r=-0.29、-0.26,P<0.05),N2P3峰值与PSI呈正相关(r=0.30,P<0.05).结论ADHD儿童存在一定程度的认知功能障碍,ERP能测量ADHD患儿的认知功能状况,ERP和韦氏智力联合使用有助于客观、全面地评价ADHD.
Objective To study the characteristics of event related potential(ERP)in children with attention deficit hyperactivity disorder(ADHD)and the correlation between ERP and hyperactivity index and intelligence,and to explore the cognitive function of children with ADHD.Methods From June 2019 to December 2020,61 children with ADHD treated in the outpatient department of Xiamen Xian Yue Hospital were selected as the study group,and 61 healthy children who met the inclusion and exclusion criteria were selected as the control group.EHP and Werhsler intelligence test were performed on children,and Conners Parent Symptom Qeustionnaire(PSQ)was performed on two groups of child caregivers.Results Under target stimulation,the P3 latency of prefrontal region,central region and parietal lobe in the study group was significantly longer than that in the control group,and the difference was statistically significant[(388.41±47.24)ms vs(372.89±34.75)ms,(395.31±55.18)ms vs(371.33±38.80)ms,(404.23±55.21)ms vs(381.54±38.93)ms;t=2.07,2.78,2.62;P<0.05].Under target stimulation,there were signifiranl differences in P3 amplitude in prefrontal region,central region and parietal lobe between the two groups[9.61(7.60,15.63)μV vs 13.52(10.04,16.90)μV,11.20(5.81,17.43)μV vs 13.49(9.22,16.54)μV,12.33(7.05,18.85)μV vs 14.74(9.31,20.09)μV;Z=-2.77,-2.10,-2.06;P<0.05].There were significant differences in speech comprehension index,perceptual reasoning index,working memory,index,processing speed index and total IQ scores between the two groups[98.0(89.0,103.5)vs 99.0(95.5,107.0),94.0(86.0,103.0)vs 100.0(89.0,109.0),85.0(75.0,97.0)vs 91.0(87.0,97.0),83.0(77.0,95.0)vs 92.0(80.5,99.0),83.0(77.0,95.0)vs 92.0(80.5,99.0);Z=-2.10,-2.54,-3.70,-3.33,-2.86;P<0.05].The hyperactivity index score of the study group was higher than that of the control group[1.80(1.60,2.10)vs 0.80(0.65,1.15);Z=9.54;P<0.05].Correlation analysis results showed that the latency of P3 was negatively correlated with working memory index(WMI)and processing speed index(PSI)(r
作者
李宗磊
王文强
吴为阁
李玉妹
钟训华
Li Zonglei;Wang Wenqiang;Wu Weige;Li Yumei;Zhong Xunhua(Deppartment of Child and Adolescent Psychology of Xiamen Xian Yue Hospital,Xiamen 361012,China;Department of Brain Evoked Potentials,Xiamen Xian Yue Hospital,Xiamen 361012,China;Department of Rehabilitation and Physical Therapy Center,Xiamen Xian Yue Hospital,Xiamen 361012,China)
出处
《神经疾病与精神卫生》
2021年第10期701-705,共5页
Journal of Neuroscience and Mental Health
基金
福建省卫生计生中青年骨干人才培养项目(2017-ZPN-93)
厦门市仙岳医院院内课题(XMXY2016-2)。
关键词
事件相关电位
认知功能
多动症
韦氏智力
Event-related potential
ADHD
Cognitive function
Werhsler intelligence
