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学龄期抽动障碍儿童提示性Go/Nogo任务的行为学及事件相关电位研究 被引量:13

Performance and electrophysiological manifestations of cued Go-Nogo test in School-age children with tic disorder
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摘要 目的通过对抽动障碍(TicDisorders,TD)患儿与正常儿童行为学及事件相关电位(Event—relatedPotentials,ERP)的比较分析,探索学龄期TD儿童持续注意与执行功能的特征。方法选择TD患儿与正常儿童各30名,采用持续性操作测试记录行为学及ERP结果。结果1.行为学:TD与正常儿童的击中数[分别为(38.07±3.04)、(38.93±1.48)]、反应时[分别为(465.427±97.00)ms、(500.17±131.29)ms]、遗漏错误数[分别为(1.97±3.02)、(1.07±1.48)]与虚报错误数[分别为(1.77±2.50)、(1.07±1.53)]均差异无统计学意义(P〉0.05)。2.ERP:①N2波幅组别与条件的主效应、交互效应均显著(P〈0.05);N2潜伏期组别与条件主效应、交互效应不均显著(P〉0.05)。②P3波幅与潜伏期均条件的主效应显著(P〈0.05),组别的主效应、组别×条件的交互效应均不显著(P〉0.05)。③抽动障碍儿童非靶N2波幅[(-1.39±3.32)]μV显著低于正常对照儿童[(-4.09±2.94)]μV(P〈0.05)。结论抽动障碍儿童任务的冲突监测可能存在损害,而持续注意与反应抑制能力与正常儿童相比无差异。 Objective To investigate beha, dor and electrophysiological manifestations of sustained atten- tion and executive function in School-age children with tic disorder (TD). Methods Sixty-six school-aged chil- dren (36 TD and 30 control) participated in a CPT-AX task. Behavioral measures and ERP measures were collect- ed. Results The 1. The Behavior results : there were no significant differences between the TD group and the con- trol group in hitting number ( ( 38.07 ± 3.04 ) , ( 38.93 ± 1.48 ) ) , reaction time ( ( 465. 427 ± 97.00 ) ms, (500.17 ± 131.29) ms) ,the number of errors of omission( ( 1.97 ± 3.02) , ( 1.07 ± 1.48) ) and the number of false errors ( ( 1.77 ± 2.50), ( 1.07 ± 1.53 ) ) (P 〉 0.05 ). 2. The ERP results : (1)Group and condition had sig- nificant main effect and interaction effect on N2 amplitude (P 〈 0.05 ), while not on the latency of N2 (P 〉 0.05 ). (2)Group had significant main effect on the amplitude and latency of P3,but main effect of Group and the interac- tion effect are not significant (P 〉 0.05 ). (3)The TD group' s amplitude of Nogo-N2 ( ( - 1.39 ± 3.321 ) μV) were smaller than that of the control group ( ( - 4.09 ± 2.94 ) μV) (P 〈 0.05 ). Conclusion Children with TD perform- ance impaired conflict monitor, while exhibit no deficits in sustained attention and response inhibition.
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2013年第9期810-813,共4页 Chinese Journal of Behavioral Medicine and Brain Science
基金 国家自然科学基金青年项目(81101018),国家自然科学基金(30870868),常州市应用基础研究计划资助项目(CJ20122016)
关键词 抽动障碍 持续注意 冲突检测 反应抑制 Tic disorder Sustained attention Conflict monitor Response inhibition
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