摘要
目的分析早期免疫治疗对不明原因复发性流产患者IL-2和IL-10水平的影响,并探讨其免疫机制,为早期诊断和治疗提供理论依据。方法选取2017年1月-2019年9月在宁波市第七医院接受治疗的80例复发性流产患者为研究对象,根据治疗时间分为孕前组和孕后组,每组各40例。测定两组患者IL-2和IL-10表达水平。将淋巴细胞应用于主动免疫治疗,比较两组患者成功妊娠率、封闭抗体水平、IL-2水平及IL-10水平。结果孕前组和孕后组患者的妊娠成功率分别为80.0%(32/40)和75.0%(30/40),差异无统计学意义(χ^(2)=0.593,P>0.05)。通过早期免疫治疗后,孕前组患者体内封闭抗体转阳率和转阴率分别为80.0%(32/40)和20.0%(8/40),孕后组患者体内封闭抗体转阳率和转阴率分别为70.0%(28/40)和30.0%(12/40),差异无统计学意义(χ^(2)=0.763,P>0.05)。治疗前,两组患者IL-2和IL-10水平比较,差异均无统计学意义(均P>0.05)。治疗后,两组患者IL-2水平下降,IL-10水平提升,且孕前组均优于孕后组,差异均有统计学意义(均P<0.05)。结论早期免疫治疗不明原因复发性流产患者效果确切,不仅能够有效改善患者IL-2、IL-10水平,且有利于妊娠顺利进行,值得临床推广。
Objective To analyze the effect of early immunotherapy on IL-2 and IL-10 levels in patients with unexplained recurrent abortion,and to explore the immune mechanism,so as to provide theoretical basis for early diagnosis and treatment.Methods A total of 80 pregnant women with recurrent abortion who received treatment in the Seventh Hospital of Ningbo from January 2017 to September 2019 were selected as the research objects.According to the treatment time,they were divided into pre-pregnancy group and post-pregnancy group,with 40 cases in each group.The expression levels of IL-2 and IL-10 were measured in two groups.The successful pregnancy rate,blocked antibody level,IL-2 level and IL-10 level were compared between the two groups.Results The success rates of pregnancy in the pre-pregnancy group and post-pregnancy group were 80.0%(32/40)and 75.0%(30/40),respectively,with no statistical significance(χ^(2)=0.593,P>0.05).After early immunotherapy,the positive and negative conversion rates of blocking antibodies in the pre-pregnancy group were 80.0%(32/40)and 20.0%(8/40),respectively,and those in the post-pregnancy group were 70.0%(28/40)and 30.0%(12/40),respectively,there was no statistical significance(χ^(2)=0.763,P>0.05).Before treatment,there was no statistically significant difference in IL-2 and IL-10 levels between two groups(all P>0.05).After treatment,the level of IL-2 decreased and the level of IL-10 increased in two groups,and the pre-pregnancy group was better than the post-pregnancy group,the differences were statistically significant(all P<0.05).Conclusion Early immunotherapy has a definite effect on the treatment of unexplained recurrent abortion,which can not only effectively improve the IL-2 and IL-10 levels of patients,but also facilitate the smooth pregnancy,and was worthy of clinical promotion.
作者
王辰焱
徐静波
蔡贤君
潘海滔
WANG Chen-Yan;XU Jing-Bo;CAI Xian-Jun(Department of gynaecology,the Seventh Hospital of Ningbo,Ningbo,Zhejiang 315200,China)
出处
《中国妇幼保健》
CAS
2021年第21期4983-4985,共3页
Maternal and Child Health Care of China
基金
浙江省医药卫生计划项目(2017KY669)。
关键词
不明原因
复发性流产
免疫治疗
炎症细胞因子
Unknown causes
Recurrent spontaneous abortion
Immunotherapy
Inflammatory cytokines
