摘要
目的探讨聚桂醇局部注射联合经导管动脉栓塞(TAE)治疗儿童富血供型血管瘤的疗效及安全性。方法收集2018年3月至2020年3月在首都儿科研究所附属儿童医院收治的64例富血供型血管瘤患儿,随机数字表法分为观察组(n=32)和对照组(n=32)。观察组患儿行聚桂醇局部注射联合TAE治疗,对照组行单纯TAE治疗。比较两组患儿的疗效及血管瘤严重程度、瘤体深度变化和并发症发生情况。结果对照组患儿每例行3~5次TAE治疗,平均3.6次;而观察组患儿每例行1~2次TAE治疗,平均1.4次,显著低于对照组(P<0.05)。治疗3个月后,观察组患儿的治疗总有效率为96.9%,显著高于对照组的81.2%(P<0.05);观察组患儿血管瘤严重程度的评分显著低于对照组(P<0.05),但两组患儿在瘤体深度及并发症的发生率方面差异无统计学意义(P>0.05)。结论聚桂醇局部注射联合TAE治疗儿童富血供型血管瘤的疗效显著,安全性高,值得临床推广。
Objective To investigate the efficacy and safety of transcatheter arterial embolization(TAE)combined with local injection of Lauromacrogol in the treatment of superficial hemangioma with rich blood supply in children.Methods A total of 64 children with hypervascular hemangioma admitted to the Children's Hospital Capital Institute of Pediatrics from March 2018 to March 2020 were randomly divided into observation group(n=32)and control group(n=32).The observation group was treated with TAE combined with Lauromacrogol local injection,while the control group was treated with TAE alone.The curative effect,severity of hemangioma,depth of tumor and incidence of complications were compared between the two groups.Results Each children in the control group was treated with TAE 3-5 times,and 3.6 times on average.Each children in the observation group was treated with TAE 1-2 times,and 1.4 times on average,which was significantly less than the control group(P<0.05).After 3 months of treatment,the total effective rate of the observation group was 96.9%,significantly higher than that of the control group(81.2%,P<0.05).The scores of hemangioma severity in the observation group was significantly lower than that in the control group(P<0.05),but there was no significant difference in tumor depth and incidence of complications between the two groups(P>0.05).Conclusion TAE combined with Lauromacrogol local injection in the treatment of hypervascular hemangioma in children has significant efficacy and high safety,which is worthy of clinical promotion.
作者
狄奇
李三林
张靖
于春欣
刘景
申刚
DI Qi;LI San-lin;ZHANG Jing;YU Chun-xin;LIU Jing;SHEN Gang(Department of Interventional Hemangioma,Children's Hospital Capital Institute of Pediatrics,Beijing 100020,China;Department of Interventional Hemangioma,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China;Department of Radiology,Children's Hospital Affiliated of Zhengzhou University,Henan Provincial Children's Hospital,Zhengzhou 450000,China)
出处
《临床药物治疗杂志》
2021年第10期40-43,共4页
Clinical Medication Journal
基金
河南省医学科技攻关计划联合共建项目(LHGJ20190950)。
关键词
血管瘤
富血供型
经导管动脉栓塞
聚桂醇
hemangioma
hypervascular
transcatheter arterial embolization
Lauromacrogol
