摘要
目的:探究胫骨横向搬移术联合负压引流(VSD)技术治疗糖尿病足的疗效及其对血管生成相关因子水平的影响。方法:根据治疗方法不同将60例糖尿病足患者分为观察组(n=28)和对照组(n=32)。对照组采用VSD技术治疗,观察组在对照组的基础上采用胫骨横向搬移术治疗。观察两组的治疗效果,对比治疗前及治疗后3个月患肢踝肱指数(ABI)、视觉模拟评分法(VAS)评分、足部血流指标(足背动脉内径、足背动脉血流速度)及血清血管生成相关因子[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、表皮生长因子(EGF)]水平。结果:观察组的临床有效率为89.29%,高于对照组的59.38%(P<0.05);治疗后,观察组ABI以及VEGF、bFGF、EGF水平均高于对照组(P<0.05),且足背动脉内径及血流速度均大于对照组(P<0.05),而VAS评分低于对照组(P<0.05)。结论:胫骨横向搬移术联合VSD技术治疗糖尿病足的临床疗效高于单用VSD,可能与其增加血管生成因子的表达水平、改善足部血供相关。
Objective:To explore clinical effectiveness of transverse tibial bone transport combined with vaccum sealing drainage(VSD)in the treatment of diabetic foot and effects on the serum levels of angiogenesis-related growth factors.Methods:60 diabetic foot patients were divided into observation group(n=28)and control group(n=32)according to different treatment methods.The control group was treated with VSD technique,and the observation group was treated with transverse tibial bone transport on the basis of the control group.The therapeutic effect of the two groups was observed,the levels of ABI,VAS score,foot blood flow index(internal diameter of the dorsal foot artery,blood flow rate of the dorsal foot artery)and angiogenesis-related growth factors[vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),epidermal growth factor(EGF)]were compared before and 3 months after treatment.Results:After treatment,the clinical effective rate of the observation group was 89.29%,which was higher than 59.38%of the control group(P<0.05).The levels of ABI,VEGF,bFGF and EGF in the observation group were higher than those in the control group(P<0.05).The diameter and blood flow velocity of dorsalis pedis artery in the observation group were higher than those in the control group(P<0.05).VAS score was lower than that in the control group(P<0.05).Conclusion:Transverse tibial bone transport combined with VSD technology is more effectivethan VSD alone in the treatment of diabetic foot,which may be related to increase the expression of serum angiogenic factor and the improvement of blood supply to the feet.
作者
何亮
周洪翔
尹东
金哲
牛杨
HE Liang;ZHOU Hong-xiang;YIN Dong;JIN Zhe;NIU Yang(Micro Hand Foot Repair and Reconstruction Ward,Department of Orthopedics,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
出处
《川北医学院学报》
CAS
2021年第10期1374-1377,共4页
Journal of North Sichuan Medical College
关键词
糖尿病足
胫骨横向搬移术
负压引流技术
血管生成相关因子
临床疗效
Diabetic foot
Transverse tibial bone transport
Vaccum sealing drainage
Angiogenesis-related growth factors
Clinical effect
