摘要
目的:探讨原发性乳腺弥漫大B细胞淋巴瘤(primary breast diffuse large B cell lymphoma,PB-DLBCL)的临床特征及磁共振成像(magnetic resonance imaging,MRI)特征,提高对该病的认识。方法:回顾并收集3例PB-DLBCL患者(均经病理学检查证实且具有完整MRI图像和临床病史资料),分析其MRI特征。结果:纳入研究的3例患者均为女性,年龄47~66岁,平均年龄(55.67±9.61)岁。病灶均分布于单侧,1例位于左乳,2例位于右乳,共6个病灶。多数病灶的边界清晰(4/6),未见边缘有毛刺(6/16),T1加权成像(T1-weighted imaging,T1WI)呈低(3/6)或等(3/6)信号,T2加权成像(T2-weighted imaging,T2WI)呈稍高信号,弥散加权成像(diffusion-weighted imaging,DWI)信号明显增高,表观弥散系数(apparent diffusion coefficient,ADC)值[(0.37~0.79)×10^(-3) mm^(2)/s]明显减低。动态增强MRI图像表现为早期病灶内部强化均匀、可见贴边血管征或血管穿行征,延迟期于病灶边缘可见“勾边强化”。时间-信号强度曲线(timesignal intensity curve,TIC)呈平台型或流出型为主。结论:PB-DLBCL的MRI表现具有一定特征,DWI对其鉴别诊断帮助较大。
Objective:To analyze the imaging features of primary breast diffuse large B cell lymphoma(PB-DLBCL)on magnetic resonance imaging(MRI)and to improve the understanding of this disease.Methods:Three PB-DLBCL patients were included in this study.All the patients were pathologically confirmed and were with complete MRI images.The findings and features of MRI images were retrospectively analyzed.Results:There were 3 females(six lesions)aged 47-66 years old,with a mean age of 55.67±9.61 years.All lesions were located on the ipsilateral side:one case in the left breast,two cases in the right breast.Most lesions demonstrated clear boundaries(4/6)without burrs on edges(6/6),isointense(3/6)or hypointense(3/6)on T1-weighted imaging(T1WI),hyperintense on T2-weighted imaging(T2WI)fat suppression sequences and sharply hyperintense on diffusionweighted imaging(DWI).The apparent diffusion coefficient(ADC)values was(0.37-0.79)×10^(-3) mm^(2)/s.Dynamic contrast enhanced MRI images showed early homogeneous enhancement of the lesions with penetrating vessels,hyperintense linear enhancement and peripheral enhancement on the delayed images.The time-signal intensity curves(TIC)were plateau type or washout type.Conclusion:PB-DLBCL has some MRI features,and DWI is of great help in its differential diagnosis.
作者
李雪
孙琨
柴维敏
严福华
LI Xue;SUN Kun;CHAIWeimin;YAN Fuhua(Department of Radiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《肿瘤影像学》
2021年第5期368-375,共8页
Oncoradiology
关键词
乳腺淋巴瘤
弥漫大B细胞淋巴瘤
磁共振成像
Breast lymphoma
Diffuse large B cell lymphoma
Magnetic resonance image
