摘要
目的:观察养阴散结法辅助化疗治疗晚期胃癌阴虚证的临床疗效。方法:将60例晚期胃癌阴虚证患者随机分成治疗组和对照组,每组各30例。对照组给予单纯化疗,治疗组在对照组基础上加服中药养阴散结方。治疗结束后,观察2组瘤体疗效、中医证候疗效、中医证候积分、生活质量(KPS)评分、化疗毒副作用及肿瘤标志物糖类抗原199(CA199)、糖类抗原125(CA125)、糖类抗原724(CA724)、癌胚抗原(CEA)、神经元特异烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)等指标情况。结果:瘤体疗效总有效率治疗组为50.00%(15/30),疾病控制率为90.00%(27/30),对照组分别为43.33%(13/30)、86.67%(26/30),2组比较,差异无统计学意义(P>0.05)。中医证候疗效总有效率治疗组为76.67%(23/30),对照组为36.67%(11/30),2组比较,差异有统计学意义(P<0.05)。治疗后2组中医证候积分较治疗前均有下降,且治疗组下降幅度大于对照组,差异均有统计学意义(P<0.05)。生活质量方面,治疗后治疗组KPS评分高于治疗前,且高于对照组,差异均有统计学意义(P<0.05)。毒副作用方面,治疗组Ⅲ~Ⅳ级骨髓抑制及消化道不良反应发生例数均少于对照组,差异有统计学意义(P<0.05)。2组治疗后血清CA199、CA125、CA724、CEA、NSE、CYFRA21-1水平较治疗前均有下降,且治疗组血清CA199、CA125下降幅度大于对照组,差异均有统计学意义(P<0.05)。结论:养阴散结法辅助化疗治疗晚期胃癌阴虚证患者疗效确切,可改善患者中医证候,提高生活质量,减少化疗毒副作用。
Objective: To investigate the clinical effect of Yin-nourishing and static blood-resolving therapy for assisting chemotherapy in the treatment of advanced gastric cancer with Yin deficiency.Methods: A total of 60 patients with advanced gastric cancer with Yin deficiency were randomly divided into treatment group and control group, with 30 patients in each group.The patients in the control group were given chemotherapy alone, and those in the treatment group were given oral administration of the traditional Chinese medicine(TCM) Yin-nourishing and static blood-resolving prescription in addition to the treatment in the control group.After treatment, the two groups were compared in terms of tumor outcome, treatment outcome of TCM syndrome, TCM syndrome score, Karnofsky Performance Scale(KPS) score, toxic and side effects of chemotherapy, and tumor markers including carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),carbohydrate antigen 724(CA724),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),and cytokeratin fragment 19(CYFRA21-1).Results: There were no significant differences between the treatment group and the control group in overall response rate [50.00%(15/30) vs 43.33%(13/30),P>0.05] and disease control rate [90.00%(27/30) vs 86.67%(26/30),P>0.05].There was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group [76.67%(23/30) vs 36.67%(11/30),P<0.05].Both groups had a significant reduction in TCM syndrome score after treatment, and the treatment group had a significantly greater reduction than the control group(P<0.05).As for quality of life, the treatment group had a significant increase in KPS score after treatment and a significantly higher KPS score than the control group(P<0.05).As for toxic and side effects, the treatment group had significantly lower numbers of cases of grade III-IV bone marrow suppression and gastrointestinal adverse reactions than the control group(P<0.05).After treatment, both groups had signifi
作者
张莉萍
王松浩
朱洁
张月峰
ZHANG Liping;WANG Songhao;ZHU Jie;ZHANG Yuefeng(Wujiang Hospital of Traditional Chinese Medicine,Suzhou 215221,Jiangsu,China)
出处
《湖南中医杂志》
2021年第9期8-12,共5页
Hunan Journal of Traditional Chinese Medicine
基金
江苏省苏州市科技发展计划项目——民生科技-医疗卫生应用基础研究(SYSD2018045)。
关键词
晚期胃癌
阴虚证
中西医结合疗法
养阴散结法
化疗
advanced gastric cancer
Yin deficiency
integrated traditional Chinese and Western medicine therapy
Yin-nourishing and static blood-resolving therapy
chemotherapy
