摘要
目的:研究外周血嗜碱性粒细胞(basophils,BASO)水平升高与超声检出良性乳腺结节发病风险的关联。方法:选取2014年01月至2019年06月接受年度健康体检,有完整血常规信息且至少有两次乳腺超声检查的受检者为研究对象,收集身高、体重、体质量指数(body mass index,BMI)、腰围(waist circumference,WC)、血压、血脂、血糖、血尿酸、血常规、婚姻状况、吸烟、饮酒、慢病史和家族史等信息。将研究对象按BASO绝对值及百分比四分位数分组,采用多因素调整的Cox比例风险回归模型分析基线BASO绝对值及百分比与良性乳腺结节发病风险的关联,计算发病风险比(HR)及其95%CI。结果:累计随访6237人年,中位随访时间2.37年,共有815人新发良性乳腺结节。多因素调整后,以BASO绝对值最低分位数组为参照,其他分位数组发生良性乳腺结节的风险增加,HR(95%CI)分别为1.19(0.98,1.45)、1.17(0.94,1.46)和1.34(1.07,1.68)(P_(趋势)<0.001)。同样,以BASO百分比最小分位数组为参照,其他分位数组发生良性乳腺结节的风险也均增加,HR(95%CI)分别为1.56(1.27,1.92)、1.53(1.23,1.91)和1.54(1.22,1.95)(P_(趋势)<0.001)。BASO百分比升高伴淋巴细胞百分比升高和单核细胞百分比升高时,乳腺结节发病风险增加,其HR(95%CI)分别为1.52(1.05,2.21)和1.38(1.02,1.87)。按年龄、BMI和WC进行分层分析发现,BASO水平升高在高年龄组(>50岁)、BMI≥28 kg/m 2组及腹型肥胖组(WC≥85 cm)人群中良性乳腺结节发病风险增加(P<0.05)。结论:外周血BASO水平升高可能增加良性乳腺结节发病风险,且该关联受年龄、BMI及WC影响。
Objective:To investigate the association between elevated basophils(BASO)and the risk of benign breast nodules detected by ultrasound among women.Methods:Persons who received annual physical examination with complete information of blood routine examination and had at least twice breast ultrasound from January 2014 to June 2019 were as the study subjects.Data on height,weight,BMI,waist circumference(WC),blood pressure,blood lipid,blood glucose,marital status,smoking status,drinking consumption,history of chronic disease,and family history of disease were collected.BASO absolute value and percentage were divided into four categories by quartile,respectively.Multivariate adjusted Cox proportional hazard model was used to analyze the association between baseline BASO and BASO%and the incidence of breast nodules.Hazard ratio(HR)and its 95%confidence interval(CI)was calculated.Results:During a total 6237 person-years of follow-up(median follow-up time of 2.37 years),815 subjects developed benign breast nodules.In the multivariable adjusted models,the lowest quartile as the reference group,the HR(95%CI)of breast nodules were 1.19(0.98,1.45),1.17(0.94,1.46),and 1.34(1.07,1.68),respectively,for BASO in the 2 nd,3 rd,and 4 th quartile(P trend<0.001).The corresponding HR(95%CI)for BSAO%in the 2 nd,3 rd,and 4 th quartile were 1.56(1.27,1.92),1.53(1.23,1.91),and 1.54(1.22,1.95)(P trend<0.001),respectively.As the percentage of lymphocytes and monocytes increased,the risk of breast nodules was increased in women who had higher percentage of BASO,with HR(95%CI)of 1.52(1.05,2.21)and 1.38(1.02,1.87),respectively.Stratified analysis were conducted by age,BMI,and WC,and the results showed that the elevated BASO were associated an increased risk of breast nodules in the elderly(>50 years),BMI≥28.0 kg/m 2,and abdominal obese(WC≥85 cm)groups(P<0.05).Conclusion:Elevated level of BASO may increase the risk of benign breast nodules,and this association is influenced by age,BMI,and WC.
作者
高鹰
魏玮
樊娜
孙绍梅
赵月
张卿
GAO Ying;WEI Wei;FAN Na;SUN Shaomei;ZHAO Yue;ZHANG Qing(Health Management Center,Tianjin Medical University General Hospital,Tianjin 300052,China;School of Public Health,Tianjin Medical University,Tianjin 300070,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第21期3755-3760,共6页
Journal of Modern Oncology
基金
国家自然科学基金(编号:71804124,71904142,71704130)
天津市自然科学基金(编号:18JCQNJC11500)。
