摘要
目的探讨罕见垂体癌患者临床特点表现、诊断、治疗方式及预后。方法分析郑州大学第一附属医院收治的5例垂体癌患者的临床表现及特点,结合文献复习,阐述垂体癌的发病机制、临床症状和治疗方式。结果垂体癌患者具有典型的垂体肿瘤侵袭的视神经受损表现和内分泌紊乱症状,通过手术结合术后病理确定诊断,术后血ACTH和PRL均明显下降,部分病人术后症状有改善,术后经化疗、放疗等综合治疗仍预后不佳,生存期为(16.20±12.69)个月。结论目前垂体癌仍很难早期诊断和彻底治疗,但最新的治疗方式使得患者的预后有所改善,病理学仍是诊断的金标准,早期尽可能手术切除配合辅助放、化疗、针对内分泌的药物治疗并与靶向治疗相结合,有可能提高长期存活率。
Objective To investigate the clinical characteristics,diagnosis,treatment and prognosis of patients with rare pituitary cancer.MethodsThe clinical manifestations and characteristics of 5 patients with pituitary carcinoma treated in the First Affiliated Hospital of Zhengzhou University were analyzed,and the pathogenesis,clinical symptoms and treatment of pituitary carcinoma were expounded in combination with literature review.ResultsThe patients had typical neuroophthalmic manifestations of pituitary tumor invasion. The diagnosis was confirmed by operation combined with postoperative pathology and immunohistochemistry. The postoperative prognosis was poor after chemotherapy and radiotherapy. The survival time were(16.20±12.69)months.Conclusion Although pituitary cancer is still difficult to diagnose and treat,the latest treatment improves the prognosis of patients,and pathology is still the gold standard of diagnosis. Early surgical resection combined with adjuvant radiotherapy,chemotherapy,endocrine drug therapy and targeted therapy may improve the long-term survival rate.
作者
马斯奇
孔腾霄
张栋韬
袁善鹏
高鹏
焦贺男
李雪元
闫东明
MA Siqi;KONG Tengxiao;ZHANG Dongtao;YUAN Shanpeng;GAO Peng;JIAO Henan;LI Xueyuan;YAN Dongming(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2021年第15期1334-1341,共8页
Chinese Journal of Practical Nervous Diseases
基金
河南省面上科学基金项目(编号:212300410401)
河南省医学科技攻关计划联合共建项目(编号:2018020043)。
关键词
垂体癌
垂体肿瘤
临床特点
发病机制
早期诊断
Pituitary carcinoma
Pituitary tumor
Clinical features
Pathogenesis
Early diagnosis
