摘要
自噬是一种常见的细胞代谢过程,其特征是形成具有双层膜结构的自噬体将胞内物质或外来异物包裹,进而与溶酶体融合进行降解。自噬对于维持细胞的稳态至关重要,自噬功能异常与多种疾病的发生发展密切相关。例如肿瘤、神经退行性疾病、病毒感染和免疫疾病等,其可能成为这些疾病潜在的治疗靶点,因此研究自噬的调控是生命科学及医学领域的热点。三结构域蛋白质(tripartite motif-containing proteins,TRIMs)家族是一类具有E3泛素连接酶活性的蛋白质,通常包含3个保守的结构域,即RING锌指结构域、B-box结构域和卷曲螺旋结构域。近年的研究发现,多个TRIM家族成员参与自噬的调控,其作用机制包括调控自噬相关的信号通路、调节自噬核心分子、作为自噬底物识别受体等。TRIM家族通过调控自噬发挥多种生物学效应,例如调节免疫、病毒防御和影响肿瘤发生发展等。本文将对TRIM家族在调控自噬过程中发挥的作用、分子机制以及通过自噬影响的生物学作用进行综述。
Autophagy is a common cellular metabolic process,which is characterized by the formation of double membrane structures named autophagosomes to degrade intracellular components or invading foreign substances to maintain cellular homeostasis.Autophagy is crucial for maintaining cell homeostasis.The dysfunction of autophagy is closely related to the occurrence and development of various diseases,including tumors,neurodegenerative diseases,viral infection,immune diseases and so on.Autophagy may be a potential therapeutic target for these diseases.Therefore,the investigation of autophagy regulation is a hot issue in life science and medical research.The TRIM(tripartite motif-containing proteins)family is a set of proteins with E3 ubiquitin ligase activity and usually contains three conserved domains,a RING zinc finger structure,a B-box structure and a coiled helix domain.Many TRIM family members have been found to play important roles in autophagy regulation,the mechanism of which include modulating autophagy-related signaling pathways,regulating autophagy core molecules and acting as autophagy receptors,etc.TRIMs participate in many biological pathways through regulating autophagy,such as immunity,virus infection and tumors.This review covers the role of TRIM proteins in regulating autophagy,the molecular mechanism and the corresponding biological effects.
作者
李玉琴
胡嘉
王琳
LI Yu-Qin;HU Jia;WANG Lin(Research Center for Tissue Engineering and Regenerative Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Clinical Laboratory,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2021年第10期1305-1313,共9页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金(No.31701202,81472740)资助。
关键词
自噬
三结构域蛋白质家族
E3泛素连接酶
肿瘤
autophagy
tripartite motif-containing proteins(TRIM)
E3 ubiquitin ligase
cancer
