摘要
三结构域(tripartite motif,TRIM)蛋白质家族成员几乎存在于所有多细胞真核生物中,它们在细胞周期、细胞凋亡、分化、代谢以及病毒的免疫应答等过程中均有重要作用,因而被广泛研究。同时,TRIM家族蛋白质在肿瘤中的作用也逐渐引起研究者的重视。该文通过讨论TRIM家族蛋白质作为泛素E3连接酶,调节核受体和p53通路等生物学功能来阐明TRIM与肿瘤发生发展的关系。
Members of the tripartite motif（TRIM） protein family are found in all multicellular eukaryotes. Genes of TRIM family are enormously studied, because they are essential for regulating cell cycle, apoptosis, differentation, metabolism and response to virus. However, researchers are now focused on their roles in cancer development. This review discussed the biological functions of TRIMs protein, including biological function as ubiquitin E3 ligases, regulation of nuclear receptors and the p53 pathway, to illuminated the relationship between TRIM proteins and tumorigenesis and cancer progression.
作者
孙静静
王淼
伍会健
Sun Jingjing Wang Miao Wu Huijian(School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China)
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第1期106-113,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81672792)
辽宁省创新团队(批准号:LT2015008)资助的课题~~
