摘要
目的研究TRIM29在非小细胞肺癌中的表达情况并探讨其临床诊断价值。方法采用免疫组化检测依兰县人民医院2011年1月~2015年1月间收治的113例非小细胞肺癌手术治疗患者癌组织中TRIM29表达情况。结果 TRIM 29在肺鳞癌与肺腺癌中阳性率较高,均有明显高表达,差异具有统计学意义（P〈0.05）,并且TRIM 29在肺鳞癌中表达强度明显高于在肺腺癌中表达,差异显著,具有统计学差异（P〈0.05）。TRIM 29表达与肺鳞癌组织分级、TNM分期及淋巴结转移呈密切正相关性（P〈0.05）,与肿瘤大小无关（P〉0.05）。TRIM 29表达与肺腺癌肿块大小、组织分级、TNM分期及淋巴结转移呈密切正相关性（P〈0.05）。且在非小细胞肺癌中TRIM 29表达与患者的性别、年龄无关（P〉0.05）。结论 TRIM29基因表达在非小细胞肺癌病理诊断中有重要意义,可提高病理诊断的正确率。
Objective To investigate the expression of TRIM29 in non small cell lung cancer and to investigate its clinical diagnostic value. Methods The expression of TRIM 29 in 113 patients with non small cell lung cancer,who treated by the people＇s hospital of Yilan county from January 2011 to January 2015, was detected by immunohistochemistry. Results The positive rate of TRIM 29 in lung squamous cell carcinoma and adenocarcinoma of the lung was significantly higher, and the difference was significant（P〈0.05）. The expression of TRIM 29 in lung squamous cell carcinoma was significantly higher than that in lung adenocarcinoma, and the difference was statistically significant（P〈0.05）. The expression of TRIM 29 was closely related to the histological grade, TNM stage and lymph node metastasis（P〈0.05）, and was not associated with tumor size（P〉0.05）. In lung squamous cell carcinoma, TRIM 29 expression was closely related to the histological grade, TNM stage and lymph node metastasis（P〈0.05）, which was not related to tumor size（P〈0.05）. And the expression of TRIM 29 in non small cell lung cancer was not related to the gender and age of the patients（P〈0.05）. Conclusion The expression of TRIM29 gene in non small cell lung cancer is of great significance, which can improve the correct rate of pathological diagnosis.
出处
《中国医药科学》
2015年第18期143-145,共3页
China Medicine And Pharmacy
关键词
TRIM29基因
非小细胞肺癌
病理
诊断
Tripartite motif-containing 29（TRIM29）
Non-small cell lung cancer
Pathology
Diagnosis
