摘要
目的探讨可溶性信号素4D(sSema4D)水平对急性ST段抬高型心肌梗死(STEMI)高血栓负荷的预测作用。方法选取STEMI确诊患者46例为STEMI组(高血栓负荷患者20例和非高血栓负荷患者26例),不稳定型心绞痛(UA)患者40例为UA组,同时选取同时间段冠状动脉造影(CAG)阴性患者40例为对照组。测定3组患者血清sSema4D水平,评估sSema4D预测冠状动脉血栓负荷的价值;分析STEMI患者中血清sSema4D与超敏C反应蛋白(hs-CRP)的相关性。结果STEMI患者的外周血中sSema4D表达水平高于对照组,STEMI高血栓负荷患者sSema4D表达量高于STEMI非高血栓负荷患者,差异有统计学意义(P<0.05)。STEMI患者中血清sSema4D与hs-CRP呈正相关(P<0.05),相关系数为0.384。结论在STEMI高血栓负荷患者中sSema4D表达水平较高,可能有一定的预测冠状动脉血栓的价值。
Objective To investigate the prediction function of soluble semaphorin 4D(sSema4D)level in acute ST segment elevation myocardial infarction(STEMI)with high thrombosis load.Methods A total of 46 patients diagnosed with STEMI were selected as STEMI group(20 patients with high thrombotic load and 26 patients without high thrombotic load),and 40 patients with unstable angina(UA)were selected as UA group.Forty patients with negative coronary angiography(CAG)during the same period were selected as control group.The serum sSema4D levels of patients in three groups were determined,and the value of sSema4D in predicting coronary thrombosis load was evaluated;the correlation between serum sSema4D level and high-sensitivity C-reactive protein(hs-CRP)in STEMI patients was analyzed.Results The expression levels of sSema4D in peripheral blood of STEMI patients were significantly higher than that of the control group,and the expression levels of sSema4D in STEMI patients with high thrombotic load were significantly higher than that of STEMI patients without high thrombotic load(P<0.05).Serum sSema4D was positively correlated with hs-CRP in STEMI patients(P<0.05),and the correlation coefficient was 0.384.Conclusion The sSema4D expression levels are higher in STEMI patients with high thrombotic load,which may be of certain value in predicting coronary thrombosis.
作者
柏洁
郑扣龙
BAI Jie;ZHENG Koulong(Department of Vasculocardiology,the Second Affiliated Hospital of Nantong University,Nantong,Jiangsu,226001)
出处
《实用临床医药杂志》
CAS
2021年第18期107-110,115,共5页
Journal of Clinical Medicine in Practice
基金
南通大学重点项目(2019LZ005)
南通市科学技术局项目(MS12020016)。
关键词
可溶性信号素4D
心肌梗死
高血栓负荷
超敏C反应蛋白
soluble semaphorin 4D
myocardial infarction
high blood clots load
high-sensitivity C-reactive protein
