摘要
近年来发现1-位芳基取代吡咯具有明显的生理效应。我们在研究β-二酮与丙烯腈反应之后,首先用乙酰丙酮与对氯-ω-溴代苯乙酮作用,得到1-对氯苯基-3-乙酰基-1,4-戊二酮(1)。然后(1)与各种不同的芳香族伯胺在乙醇和冰醋酸的混合溶剂中(体积比3:4)进行环合反应,生成1,2,3,5-四取代吡咯(2)至(10)。而后(2)至(9)分别与氨基脲反应,得到相应的缩氨脲。这些都是新化合物,其性质见附表。
Acetylacetone was treated by p-chloro-ω-bromoacetophenone to give 1-(p-ch-lorophenyl)-3-acetyl-l,4-pentandiketone (1). Nine new 1-aryl-2-methyl-3-acetyl--5-(p-chlorophenyl) pyrroles (2)-(10) have been synthesized by the reaction of (1) with various primary amines. Semicarbazones (11)-(18) were prepared from (2)-(9).Compounds (1)-(18) are reported for the first time.
作者
李葆
张书文
Li Bao;Zhang Shuwen(Department of Chemistry,Jilin Teacher's College,Jilin)
出处
《高等学校化学学报》
SCIE
EI
CAS
1985年第4期341-342,共2页
Chemical Journal of Chinese Universities
