摘要
1963年比利时生物化学家Duve第一次使用自噬(autophagy)这一名称,他同时因发现溶酶体获得了1974年的诺贝尔生理学或医学奖。日本科学家大隅良典因发现了细胞自噬机制而荣获2016年诺贝尔生理学或医学奖。目前认为细胞自噬是一种溶酶体依赖的细胞降解途径。自噬包括生理状态下的基础自噬以及应激状态下所诱导的自噬[1],在肾脏固有细胞的生理及病理过程中均发挥重要作用。
Autophagy is an evolutionarily conserved pathway for the removal of damaged cells and organelles as well as aggregated proteins and intracellular pathogens. A growing body of evidence supports that the aberrant autophagic lysosomal pathway contributes to the pathogenesis of kidney diseases. Nevertheless,a comprehensive evidence-based consensus still needs to be further established for investigation of autophagy in the field of nephrology. Therefore,the Committee of Chinese Association of Pathophysiology,Society of Nephrology(CAPN)invited Chinese nephrologists to develop this expert consensus by critically reviewing the available literature in the field of autophagy,especially the impact on kidney diseases. The aim is to provide a useful reference for clinical and basic research on autophagy in kidney diseases.
作者
中国病理生理学会肾脏病专业委员会
刘华锋
杨俊伟
Chinese Association of Pathophysiology,Society of Nephrology;LIU Hua-feng;YANG Jun-wei(不详;Institute of Nephrology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Center for Kidney Disease,The Second Affiliated Hospital,Nanjing Medical University,Nanjing 210003,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2021年第10期1876-1887,共12页
Chinese Journal of Pathophysiology
关键词
自噬
肾脏疾病
专家共识
Autophagy
Kidney diseases
Expert consensus
