摘要
肾间质纤维化是以细胞外基质过度积聚和成纤维细胞的增殖为病理特点,似属中医微观辨证之瘢积范畴。“虚、痰(浊)、瘀、毒”是导致肾间质纤维化发生、发展的关键。四者之中虚是肾间质纤维化的始动因素,痰(浊)、瘀是构成肾间质纤维化的病理基础,而毒是加重肾间质纤维化不可忽视的方面。其病机为本虚标实,虚实兼夹。治疗原则为消补兼施、标本兼治。
Renal interstitial fibrosis (RIF) is pathologically character- ized by excessive accumulation of extracellular matrix and proliferation of fibroblast,probably attributive to the category of abdominal mass in micro- scopic TCM syndrome differentiation.It is considered that deficiency, phlegm,blood-stasis and toxic substance are the cruxes of occurrence and development of RIF.Among them,deficiency is the initial factor,phlegm and blood-stasis are the pathological base and toxic substance is the ag- gregated factor of RIF.Its pathogenesis is deficiency in root aspect and ex- cess in secondary aspect,and coexistence of deficiency and excess.Its therapeutical principle is combination of dispersion and invigoration,and treatment of primary and secondary aspects.
出处
《新中医》
CAS
北大核心
2006年第11期1-3,共3页
New Chinese Medicine
