摘要
肝细胞癌发生发展机制复杂,目前尚未完全阐明。KLF4又称为胃肠富集Krüppel样因子,具有抑癌和促癌的双重调节作用。KLF4在肝癌中发挥抑癌作用,介绍了KLF4在肝癌发展过程中的生物学功能及调控机制,研究KLF4在肝癌中作用机制有望为肝癌的靶向治疗和预后监测提供新思路。
The pathogenesis of hepatocellular carcinoma is complex and has not been fully clarified.KLF4,also known as gut-enriched Kruppel-like factor(GKLF),plays the dual regulatory role of tumor suppressor and tumor promoter.KLF4 plays an anti-cancer role in liver cancer.This article introduces the biological function and regulatory mechanism of KLF4 in the progression of liver cancer,and research on the mechanism of action of KLF4 in liver cancer is expected to provide new ideas for targeted therapy and prognosis monitoring of liver cancer.
作者
孙菲
苏维玮
付艳华
王经伟
SUN Fei;SU Weiwei;FU Yanhua;WANG Jingwei(Department of Hepatology,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao,Shandong 266035,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第10期2452-2455,共4页
Journal of Clinical Hepatology
基金
山东大学齐鲁医院(青岛)青年项目基金(QDKY2020QN17)。
关键词
癌
肝细胞
Kruppel样转录因子类
生物学功能
分子机制
Carcinoma,Hepatocellular
Kruppel-Like Transcription Factors
Biological Function
Molecular Mechanism
