摘要
目的探讨血清kruppel样因子4(KLF4)、可溶性p选择素(Ps)对子痫前期的预测价值。方法选取2019年6月至2021年6月该院收治并确诊的116例子痫前期患者作为研究对象,根据疾病严重程度分为轻度组(62例)、重度组(54例)。另外选取40例同期来该院体检的健康孕妇作为对照组。采用酶联免疫吸附试验检测血清KLF4、Ps水平,并进行各组间的比较;采用受试者工作特征(ROC)曲线分析血清KLF4、Ps对子痫前期的预测价值;采用多因素Logistic回归分析影响子痫前期的相关因素。结果血清KLF4水平在重度组、轻度组、对照组中依次升高,血清Ps水平在重度组、轻度组、对照组中依次降低,两两比较差异均有统计学意义(P<0.05)。血清KLF4、Ps预测子痫前期的曲线下面积(AUC,95%CI)分别为0.769(0.719~0.818)、0.832(0.881~0.882),截点值分别为42.73、112.95 pg/mL,特异度分别为50.00%、67.50%,灵敏度均为93.10%,二者联合检测预测的AUC(95%CI)为0.921(0.870~0.971),特异度为85.00%,灵敏度为86.20%。年龄>35岁(OR=2.16,95%CI:1.31~3.56)、有高血压史(OR=2.28,95%CI:1.33~3.91)、KLF4水平降低(OR=3.01,95%CI:1.47~6.18)、Ps水平升高(OR=2.57,95%CI:1.39~4.75)是发生子痫前期的危险因素(P<0.05)。结论KLF4水平降低、Ps水平升高是发生子痫前期的危险因素,KLF4、Ps能够作为预测子痫前期的实验室指标,且二者联合检测的预测价值更高。
Objective To investigate the predictive value of serum kruppel-like factor 4(KLF4)and soluble p-selectin(Ps)in preeclampsia.Methods A total of 116 patients with preeclampsia who were admitted and diagnosed in this hospital from June 2019 to June 2021 were selected as the research subjects,and divided into mild group(62 cases)and severe group(54 cases)according to the severity of the disease.In addition,40 healthy pregnant women who came to this hospital for physical examination during the same period were selected as the control group.The levels of serum KLF4 and Ps were detected by enzyme-linked immunosorbent assay,and the levels of KLF4 and Ps were compared among the three groups.The predictive value of serum KLF4 and Ps for preeclampsia was analyzed by receiver operating characteristic(ROC)curve.The related factors affecting preeclampsia were analyzed by multivariate Logistic regression.Results The serum KLF4 level increased in the severe group,mild group and control group in turn,while the serum Ps level decreased in the severe group,mild group and control group in turn,the differences were statistically significant(P<0.05).The area under the ROC curve(AUC,95%CI)of serum KLF4 and Ps for predicting preeclampsia were 0.769(0.719—0.818)and 0.832(0.881—0.882)respectively,and the cut-off values were 42.73,112.95 pg/mL respectively,the specificities were 50.00%,67.50%,the sensitivities both were 93.10%respectively.The prediction AUC(95%CI)of the two indicators combined detection was 0.921(0.870—0.971),the specificity was 85.00%,the sensitivity was 86.20%.Age>35 years old(OR=2.16,95%CI:1.31—3.56),history of hypertension(OR=2.28,95%CI:1.33—3.91),decreased KLF4(OR=3.01,95%CI:1.47—6.18)and elevated Ps(OR=2.57,95%CI:1.39—4.75)were risk factors for preeclampsia(P<0.05).Conclusion Decreased KLF4 level and elevated Ps level are risk factors for the occurrence of preeclampsia,and the two indicators could be used for predicting preeclampsia,and the combined detection of the two indicators has a higher predictiv
作者
沈娟
王泯蓉
李思吟
SHEN Juan;WANG Minrong;LI Siyin(Department of Obstetrics and Gynecology,Mianyang Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China/Mianyang Central Hospital,Mianyang,Sichuan 621000,China;Department of Rheumatology and Immunology,Mianyang Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China/Mianyang Central Hospital,Mianyang,Sichuan 621000,China)
出处
《国际检验医学杂志》
CAS
2022年第21期2583-2586,共4页
International Journal of Laboratory Medicine
基金
四川省卫生健康委员会医学科技项目(21PJ180)。
