摘要
目的探讨不同糖耐量阶段女性绝经前后雌二醇(E2)与胰岛素抵抗、血糖等代谢指标的关系。方法选取2014年9月-2016年9月在我院内分泌科门诊行健康检查的328名女性为研究对象,按照是否绝经分为绝经前组(n=159)和绝经后组(n=169),绝经后组根据糖耐量状态分为正常糖耐量组(NGT组n=50)、糖调节受损组(IGR组n=70)和2型糖尿病组(T2DM组n=49)。分析绝经前后女性相关代谢指标的变化及E2与相关代谢指标的关系,以及不同糖耐量水平女性E2的变化。结果绝经后组年龄、收缩压、LDL-C、FPG、2h PG、HbA1c、空腹胰岛素、HOMA-IR高于绝经前组,BMI、E2低于绝经前组,差异有统计学意义(P<0.05)。两组E2水平与BMI、空腹胰岛素及HOMA-IR呈负相关(P<0.05),与其他代谢指标无相关性(P>0.05)。NGT组E2水平高于IGR组和T2DM组,差异有统计学意义(P<0.05)。结论在不同糖耐量阶段的人群中,绝经后女性的胰岛素抵抗程度明显高于绝经前女性,且女性E2水平与胰岛素抵抗呈明显负相关。
Objective To investigate the relationships among estradiol(E2)and insulin resistance,blood sugar and other metabolic indicators in premenopausal and postmenopausal women with different glucose tolerance.Methods A total of 328 women who underwent health examination in endocrinology clinic of our hospital from September 2014 to September 2016 were selected and divided into premenopausal group(n=159)and postmenopausal group(n=169)according to whether menopause or not.The postmenopausal group was divided into normal glucose tolerance group(NGT group,n=50),impaired glucose regulation group(IGR group,n=70)and type 2 diabetes group(T2DM group,n=49)according to the state of glucose tolerance.The changes of related metabolic indexes in premenopausal and postmenopausal women,the relationship between E2 and related metabolic indexes,and the changes of E2 in women with different glucose tolerance levels were analyzed.Results The Age,systolic blood pressure,LDL-C,FPG,2h PG,HbA1c,fasting insulin and HOMA-IR in postmenopausal group were higher than those in premenopausal group,while BMI and E2 were lower than those in premenopausal group,and the difference was statistically significant(P<0.05).The E2 levels in the two groups were negatively correlated with BMI,fasting insulin and HOMA-IR(P<0.05),had no correlation with other metabolic indexes(P>0.05).The E2 level in NGT group was higher than that in IGR group and T2DM group,and the difference was statistically significant(P<0.05).Conclusions In the population with different glucose tolerance stages,the insulin resistance of postmenopausal women is significantly higher than that of premenopausal women,and the level of female E2 is significantly negatively correlated with insulin resistance.
作者
李翠柳
马洁
高芳
王光亚
郭宁宁
殷秀平
张云娜
王霖霞
LI Cui-liu;MA Jie;GAO Fang;WANG Guang-ya;GUO Ning-ning;YIN Xiu-ping;ZHANG Yun-na;WANG Lin-xia(The Second Department of Endocrinology,Cangzhou Central Hospital,Cangzhou 061000,Hebei,China)
出处
《医学信息》
2021年第20期112-114,共3页
Journal of Medical Information
关键词
绝经
胰岛素抵抗
雌二醇
糖调节受损
Menopausal
Insulin resistance
Estradiol
Impaired glucose regulation
