摘要
目的探讨老年高血压患者血清晚期糖基化终末产物(AGEs)水平及其与认知功能障碍的相关性。方法选取河南省某中心2017年10月-2019年10月收治的62例老年高血压患者作为研究对象,采用简易智力状况量表(MMSE)将患者分为认知障碍组(n=14)与认知正常组(n=48)。记录患者一般临床资料,比较2组患者血压、血脂及AGEs水平,分析AGEs水平与认知功能障碍的相关性。结果认知正常组患者甘油三酯(TG)水平高于认知障碍组,而高密度脂蛋白胆固醇(HDL-C)、AGEs水平低于认知障碍组,差异均有统计学意义(P<0.05);2组患者空腹血糖(FPG)、总胆固醇(TC)、收缩压(SBP)及舒张压(DBP)水平比较,差异无统计学意义(P>0.05);Logistic回归分析结果发现,年龄≥75岁、文化程度小学及以下、AGEs≥10.56 p/(mg·L)是影响老年高血压患者认知功能的危险因素(P<0.05)。结论老年高血压患者血清AGEs水平升高可能是造成其认知功能障碍的危险因素之一,应密切监测。
Objective To investigate the levels of serum advanced glycosylation end products(AGEs)in elderly hypertensive patients and their correlation with cognitive dysfunction.Methods Sixty-two elderly hypertensive patients admitted to a Center in Henan Province from October 2017 to October 2019 were selected as study subjects,and the patients were divided into cognitive impairment group(n=14)and cognitive normal group(n=48)using the Mini-Mental State Examination(MMSE).General clinical data were recorded,blood pressure,lipids and AGEs levels were compared between the two groups,and the correlation between AGEs levels and cognitive impairment was analyzed.Results The levels of triglycerides(TG)in the cognitively normal group were higher than those in the cognitively impaired group,while the levels of high-density lipoprotein cholesterol(HDL-C)and AGEs were lower than those in the cognitively impaired group,and the differences were statistically significant(P<0.05);the differences were not statistically significant when comparing the levels of fasting plasma glucose(FPG),total cholesterol(TC),systolic blood pressure(SBP)and diastolic blood pressure(DBP)in the two groups(P>0.05);Logistic regression analysis revealed that age≥75 years,education level of elementary school or below,and AGEs≥10.56 p/(mg·L)were risk factors affecting cognitive function in elderly hypertensive patients(P<0.05).Conclusion Elevated levels of serum AGEs in elderly hypertensive patients may be one of the risk factors for their cognitive dysfunction and should be closely monitored.
作者
赵娜
李博
胡松涛
Zhao Na;Li Bo;Hu Songtao(Outpatient Department,Shangqiu Disease Prevention and Control Center,Shangqiu Henan 476000,China;Department of Geriatrics,Shangqiu Chinese Hospital,Shangqiu Henan 476000,China;Laboratory,Shangqiu Disease Prevention and Control Center,Shangqiu Henan 476000,China)
出处
《保健医学研究与实践》
2021年第4期74-77,共4页
Health Medicine Research and Practice
基金
河南省科技攻关计划项目(201703364)。
关键词
老年人
高血压
血清晚期糖基化终末产物
认知功能障碍
Elderly
Hypertension
Serum advanced glycosylation end products
Cognitive dysfunction
