摘要
原发性胃淋巴上皮瘤样癌(LELC)是胃癌中的一种罕见组织学类型,属于EB病毒相关性胃癌(EBVaGC)中的一种,占胃癌的1%~7%。其临床表现无特异性,诊断主要依靠病理组织学检查。手术治疗适用于该病,细胞程序性死亡-配体1(PD-L1)抑制剂在该病的治疗效果可能优于胃腺癌,预后可能较非胃LELC好。由于该病在世界范围内少见,目前针对胃LELC且形成广泛统一共识的诊疗方案未被提出,而它与常见的胃腺癌相比具有某些不同的疾病特点。本文根据相关文献从流行病学特征、临床诊治方法、病理学表现、预后这4个方面综述了LELC的临床诊治现况,以期为临床医生提供参考。
Primary lymphoepithelioma-like gastric carcinoma(LELGC)is a rare histological type of gastric carcinoma,which belongs to one of Epstein-Barr virus-associated gastric carcinoma(EBVaGC),accounting for about 1%-7%of gastric carcinoma.Its clinical manifestations are non-specific,and the diagnosis mainly relies on pathological histological examination.Surgical treatment is indicated for this disease,and programmed cell death-Ligand 1(PD-L1)inhibitors may be more effective in this disease than ingastric adenocarcinoma,and the prognosis may be better than non-LELGC.Because the disease is rare around the world,no treatment protocol has been proposed for LELGC with a broad consensus,and it has certain different disease characteristics compared with common gastric adenocarcinoma.Based on relevant literatures,this paperreviews the status quo of clinical diagnosis and treatment of LELGC in terms of four aspects:epidemiological features,clinical diagnosis and treatment methods,pathological manifestations,and prognosis,in order to provide reference for clinicians.
作者
张锐
夏利刚
ZHANG Rui;XIA Ligang(Second Clinical Medical College of Ji'nan University,Guangdong,Shenzhen 518020,China;Department of Gastrointestinal Surgery,Shenzhen People's Hospital,Guangdong,Shenzhen 518020,China)
出处
《中国医药科学》
2021年第17期42-46,共5页
China Medicine And Pharmacy
关键词
胃淋巴上皮瘤样癌
EB病毒相关性胃癌
流行病学
诊断
治疗
预后
进展
Lymphoepithelioma-like gastric carcinoma
Epstein-Barr virus-associated gastric carcinoma
Epidemiology
Diagnosis
Treatment
Prognosis
Advances
