摘要
目的 了解北京市通州区成人非伤寒沙门菌耐药性特征,为制定防治策略提供参考。方法 采用微量肉汤稀释法(MIC法)对2015年-2019年北京市通州区2所哨点医院监测并分离到的59株成人沙门菌进行血清型分析和8类13种抗生素药敏试验。结果 2015年-2019年北京市通州区共检测成人腹泻粪便标本1 817份,非伤寒沙门菌检出率为3. 25%(59/1817)。所有沙门菌株对13种抗生素均存在不同程度耐药,其中对喹诺酮类(萘啶酸)耐药率最高(49. 2%);对氨苄西林、氨苄西林/舒巴坦、四环素、萘啶酸、头孢唑啉5种抗生素耐药率均超过30%;多重耐药谱分14种,其中以氨苄西林-氨苄西林/舒巴坦-萘啶酸-头孢唑啉占比最高(30%)。结论 北京市通州区成人非伤寒沙门菌主要耐药抗生素为喹诺酮类和青霉素类药物且存在多重耐药特征,耐药谱广泛,应加强耐药监测。
Objective To understand the characteristics of Non-typhoid Salmonella tolerance in adults in Tongzhou District,so as to provide prevention,control and treatment strategies.Methods Serum type analysis and antimicrobial susceptibility tests of 13 strains of Salmonella were performed on 59 strains of adult Salmonella strains monitored and isolated from 2 sentinel hospitals in Tongzhou District from 2015 to 2019 by microbroth dilution method(MIC).Results A total of 1817 samples of adult diarrhea feces were detected in Tongzhou District from 2015 to 2019,the detection rate of Non-typhoid Salmonella was 3.25%(59/1817).The results showed that all Salmonella strains had different levels of resistance to 13 antibiotics,among which the highest rate of NAL(naproxic acid)resistance was 49.2%.The multidrug-resistant strains were divided into 14 types,among which AMP-AMS-NAL-CFZ accounted for the highest proportion(30%).Conclusion The main antibiotic-resistant antibiotics of adult Non-typhoid Salmonella in Tongzhou District are quinolones and penicillins,and they have the characteristics of multi-drug resistance,and the drug resistance spectrum is wide,so the drug resistance monitoring should be strengthened.
作者
江南
张萍
吴建军
聂静雨
马晓晨
JIANG Nan;ZHANG Ping;WU Jian-jun;NIE Jing-yu;MA Xiao-chen(Tongzhou District Center for Disease Control and Prevention,Beijing 101100,China;不详)
出处
《中国卫生检验杂志》
CAS
2021年第18期2213-2216,共4页
Chinese Journal of Health Laboratory Technology
基金
国家重点研发计划(2017YFC1601502)。
关键词
非伤寒沙门菌
耐药特征
血清型
成人
Non-typhoid Salmonella\Drug resistance characteristics
Serum type
Adult
