摘要
目的 研究人附睾蛋白4(HE4)及睾酮(TES)在前列腺疾病诊断中的应用。方法 收集本院泌尿外科诊断为前列腺疾病伴TPSA升高患者的外周血113例,同时收集匹配年龄段体检者外周血40例。化学发光法检测TPSA、FPSA、TES及HE4,利用SPASS 21. 0分析检测结果,HE4、TES与TPSA浓度变化的相关性采用相关分析;正常组与疾病组间以及疾患组内不同浓度分组间HE4及TES浓度比较均采用单因素方差分析;ROC曲线分析HE4与TES分别以及联合对前列腺疾病的诊断效能。结果 HE4、TES的浓度与TPSA浓度变化分别呈正相关关系(r=0. 291,P <0. 01)和负相关关系(r=-0. 188,P <0. 05),HE4与TES的浓度变化呈负相关关系(r=-0. 313,P <0. 01);健康体检组与疾病组间HE4和TES浓度比较差异有统计学意义(P <0. 05),HE4在TPSA 4. 0 ng/ml~10. 0 ng/ml和> 10. 0 ng/ml组与体检组之间差异均有统计学意义(P <0. 05),TES仅在TPSA>10. 0 ng/ml组与体检组间差异有统计学意义;HE4在体检组与FPSA/TPSA <0. 16及≥0. 16组间差异均有统计学意义(P <0. 05),而TES仅<0. 16组与体检组间差异有统计学意义(P <0. 05);HE4的AUC为0. 691,TES的AUC为0. 623,两者联合的AUC为0. 689。结论 HE4和TES浓度监测均有助于前列腺疾病的诊断,HE4的诊断效能更高。
Objective To study the application of human epididymal protein 4(HE4)and testosterone(TES)in the diagnosis of prostate diseases.Methods A total of 113 peripheral blood samples were collected from patients diagnosed as prostate diseases with elevated TPSA by the urology department of our hospital,and 40 peripheral blood samples were collected from those who underwent physical examination in a matched age group.TPSA,FPSA,TES and HE4 were detected by chemiluminescence method.SPASS 21.0 was used to analyze the detection results.Correlation analysis was used for the correlation between HE4,TES and TPSA concentration changes.The concentrations of HE4 and TES were compared between the normal group and the disease group,as well as between different concentration groups in the disease group by one-way analysis of variance.ROC curve was used to analyze the diagnostic efficacy of HE4 and TES respectively and in combination for prostate diseases.Results The concentration of HE4 was positively correlated with TPSA concentration(r=0.291,P<0.01)and negatively correlated with the concentration of TES(r=-0.188,P<0.05),and the HE4 and TES was negatively correlated(r=-0.313,P<0.01);There was statistical significance on the differences in HE4 between TPSA 4.0 ng/ml to 10.0 ng/ml and>10.0 ng/ml groups and the physical examination group(P<0.05),while there was statistical significance on the differences in TES only between TPSA>10.0 ng/mL and the physical examination group;the differences of HE4 between the physical examination group and THE FPSA/TPSA<0.16 and 16 groups were statistically significant(P<0.05).The differences of TES were only statistically significant between the physical examination group and the FPSA/TPSA<0.16 and M0.16 groups(P<0.05).The AUC of HE4 was 0.691,the AUC of TES was 0.623,and the combined AUC of them was 0.689.Conclusion The concentration monitoring of HE4 and TES is helpful to the diagnosis of prostate diseases,and the diagnostic efficiency of HE4 is higher.
作者
袁园
李金笑
陈菊萍
樊德利
许超
刘玉华
YUAN Yuan;LI Jin-xiao;CHEN Ju-ping;FAN De-li;XU-Chao;LIU Yu-hua(Clinical Laboratory,Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China;不详)
出处
《中国卫生检验杂志》
CAS
2021年第18期2177-2180,共4页
Chinese Journal of Health Laboratory Technology
基金
国家自然科学基金资助课题(81701568)。
关键词
前列腺
前列腺特异性抗原
人附睾蛋白4
睾酮
Prostate
Prostate-specific antigen
Human epididymal protein 4
Testosterone
