摘要
目的:探究针刺配合八正散治疗湿热下注Ⅲ型慢性前列腺炎(CP/CPPS)患者的临床效果。方法:前瞻性选取2018年9月-2019年9月医院男科收治的60例CP/CPPS患者为研究对象,按随机数字表法随机分成对照组(n=30)、观察组(n=30),对照组采用常规治疗,观察组为针刺联合八正散治疗。采用慢性前列腺炎症状指数量表(NIH-CPSI)动态评估临床疗效,放射免疫法测定血清前列腺素E2(PGE-2)、雌二醇(E2)、睾酮(T)水平,酶联免疫吸附法(ELISA)检测血清TNF-α、IL-10水平,并统计两组患者不良反应、复发情况。结果:两组患者不同时点NIH-CPSI评分在时间因素、组别因素及时间与组别的交互因素影响下差异显著(P<0.05);组内比较,两组患者NIH-CPSI评分均随时间延长而显著下降(P<0.05);组间比较,治疗2周、治疗4周、治疗3个月后观察组患者NIH-CPSI评分均显著低于对照组患者(P<0.05)。两组患者不同时点血清PGE-2、E2/T、TNF-α、IL-10水平在时间因素、组别因素及时间与组别的交互因素影响下差异显著(P<0.05);组内比较,两组患者治疗4周后血清PGE-2、E2/T、TNF-α、IL-10水平均显著下降(P<0.05);组间比较,观察组患者血清PGE-2、E2/T、TNF-α、IL-10水平均显著低于对照组患者(P<0.05)。两组患者并发症发生率及复发率比较均无显著差异(P>0.05)。结论:对CP/CPPS患者行针刺联合八正散治疗,可有效降低患者炎症反应、改善患者临床症状、提高生活质量,且安全性高。
Objective:Exploration of acupuncture and Bazheng powder for the treatment of dampness-heat type patients with chronic prostatitis(CP/CPPS)clinical effect.Methods:A total of 60 CP/CPPS patients admitted to our hospital from September 2018 to September 2019 were prospectively selected as study subjects.The control group(n=30)was treated with conventional therapy,while the observation group(n=30)was treated with acupuncture combined with Bazheng powder.The clinical efficacy of NIH-CPSI was evaluated dynamically,serum levels of PGE-2,E2 and T were measured by radioimmunoassay,serum levels of TNF-αand IL-10 were detected by ELISA,and the adverse reactions and recurrence of patients in the two groups were counted.Results:The NIHCPSI scores of patients in two groups at different time points were significantly different under the influence of time factor,group factor and interaction factor between time and group(P<0.05).The NIH-CPSI scores of patients in both groups decreased significantly with the extension of time(P<0.05).The NIH-CPSI scores of patients in the observation group at after 2 weeks,4 weeks and 3 months of treatment were significantly lower than those in the control group(P<0.05).The serum levels of PGE-2,E2/T,TNF-αand IL-10 in the 2 groups at different time points were significantly different under the influence of time factor,group factor and interaction factor between time and group(P<0.05).After 4 weeks of treatment,serum levels of PGE-2,E2/T,TNF-αand IL-10 in both groups were significantly decreased(P<0.05).The serum levels of PGE-2,E2/T,TNF-αand IL-10 in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in complication rate and recurrence rate between the two groups(P>0.05).Conclusion:Acupuncture combined with Bazheng powder therapy in CP/CPPS patients can effectively reduce inflammatory response,improve clinical symptoms,and improve quality of life,with high safety.
作者
何望
陈其华
He Wang;Chen Qihua(Hunan University of Traditional Chinese Medicine,Changsha 410208,China;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,China)
出处
《亚太传统医药》
2021年第3期88-91,共4页
Asia-Pacific Traditional Medicine
基金
湖南省科技创新平台与人才计划(2018SK4012)
关键词
型慢性前列腺炎
针刺
八正散
炎症反应
CP/CPPS
Acupuncture
Bazheng Powder
Inflammatory Response
