摘要
目的探究富含脯氨酸蛋白11(PRR11)在脑胶质瘤组织中的表达情况,以及PRR11与临床病理和预后的关系。方法在TCGA数据库中比较PRR11在胶质瘤组织和正常脑组织中表达差异及临床预后等生物学信息。收集58例在临沂市人民医院行脑胶质瘤手术患者的临床资料和胶质瘤组织标本以及20例脑外伤患者颅内减压后的脑组织标本。以减压后脑组织作为对照,利用免疫组织化学等方法检测脑胶质瘤组织中PRR11蛋白表达情况,分析PRR11表达水平与临床病理参数之间的相关性,通过生存曲线比较PRR11表达与患者预后之间的关系。结果PRR11在胶质瘤组织高表达率为37.9%(22/58),减压后脑组织PRR11高表达率为5.0%(1/20),两者相比,差异具有统计学意义(P=0.027)。脑胶质瘤组织中PRR11表达情况与患者WHO分级、Ki-67、p53基因型有关(P<0.05),而与患者年龄、性别、肿瘤位置、肿瘤大小、KPS评分均无关(P>0.05)。PRR11低表达的胶质瘤患者生存时间高于高表达的患者生存时间,两者差异有统计学意义(P=0.0023)。结论PRR11在胶质瘤组织中表达增高,且PRR11表达与胶质瘤病理分级及患者生存期密切相关。
Objective To investigate the expression of proline-rich protein 11(PRR11)in glioma and its relationship with clinicopathological parameters.Methods The expression of PRR11 in gliomas and normal brain tissues and clinical prognosis were compared in TCGA database.58 patients with gliomas were selected randomly after neurosurgical resection.At the same time,20 cases of normal brain tissue resected with severe craniocerebral trauma.The expression of PRR11 in glioma was detected by immunohistochemistry.The correlation between PRR11 expression level and clinicopathological pa⁃rameters was studied by statistical method.The prognosis difference between high expression and low expression patients was compared by the drawing of survival curve.Results The high expression rate of PRR11 was 37.9%(22/58)in glioma tissues and 5.0%(1/20)in brain tissues after decompression.There was significant difference between the two groups(P=0.027).The expression of PRR11 was correlated with WHO grade,Ki-67 and p53 genotype(P<0.05),but not with age,gender,tumor location,tumor size and KPS score(P>0.05).The survival time of patients with low expression of PRR11 was significantly higher than that of patients with high expression of PRR11(P=0.0023).Conclusion The expression of PRR11 in glioma tissue was increased,and the expression of PRR11 was related to the pathological grade and survival time.
作者
张权
白吉林
张志龙
孙强
薛正淳
张墨轩
张健
ZHANG Quan;BAI Ji-Lin;ZHANG Zhi-Long;SUN Qiang;XUN Zheng-Chun;ZHANG Mo-Xuan;ZHANG Jian(Weifang Medical University,Weifang,Shandong 261053,China;Department of Neurosurgery,Linyi People’s Hospital,Linyi,Shandong 276000,China)
出处
《国际神经病学神经外科学杂志》
2021年第4期349-353,共5页
Journal of International Neurology and Neurosurgery
基金
山东省自然科学基金(ZR2015HL044)。
关键词
胶质瘤
富含脯氨酸11
临床病理
预后
proline rich protein 11
glioma
pathological grade
prognosis