摘要
目的分析我院抗菌药物致药品不良反应(ADR)及皮试阳性的特点,为临床安全合理使用抗菌药物提供参考依据。方法收集我院2014年1月—2020年2月上报的624份抗菌药物ADR报告,按照患者基本情况、药物种类、给药途径、临床表现、发生时间、恢复时间等情况进行回顾性分析。结果624例中有196例为皮试阳性,196例皮试阳性报告中女性(56.12%)多于男性(43.88%),其中≤10岁的患者最多(38.78%);皮试阳性的症状以皮丘隆起、有伪足、红晕、瘙痒为主,皮丘的直径平均为1.88cm;发生时间及恢复时间在16~30min多见。428例为使用药品过程发生ADR的患者,其中也是女性(58.18%)多于男性(41.82%),男女性别比为1:1.39,以21~30岁年龄段的患者最多;以粉针剂静脉滴注发生ADR数量最多;品种头孢菌素最常见,其次为喹诺酮类药物;累及的系统以皮肤及其附件最多,其次为消化系统和循环系统。发生不良反应的时间0~30min占绝大多数(60.18%),恢复时间多以16~30min。结论进一步重视和加强抗菌药物ADR的监测及详细上报工作,详细询问,确保患者用药安全。
Objective To analyze the characteristics of adverse drug reactions(ADR)and positive skin test of antimicrobial agents in our hospital,and to provide references for the safe and rational use of antimicrobial agents in clinical practice.Methods A total of 624 antimicrobial ADR reports were collected from our hospital from January 2014 to February 2020,and retrospectively analyzed according to patients'basic conditions,drug types,drug administration,clinical manifestations,occurrence time and recovery time.Results 196 cases were skin positive of the 624 cases,among the 196 cases of skin test positive report,females(56.12%)were more than males(43.88%),among which patients≤10 years old were the most(38.78%).The symptoms of positive skin test were mainly cutaneous humulus uplift,pseudopodia,redness,and itching.The diameter of cutaneous humulus was 1.88cm on average.The occurrence time and recovery time was common in the range of 16~30min.Among the 428 patients with ADR during drug use,female patients(58.18%)were more than male patients(41.82%),and the male-female sex ratio was 1:1.39,with the most patients aged 21~30 years old.The amount of ADR in intravenous infusion of powder was the largest.Cephalosporins were the most common,followed by quinolones.The skin and its accessories were the most involved systems,followed by the digestive and circulatory systems.The time of adverse reactions was 0~30min(60.18%),and the recovery time was 16~30min.Conclusion More attention should be paid to the monitoring and detailed report of antimicrobial ADR to ensure the drug safety of patients.
作者
罗骞
高楚
曾洁
朱莉娜
欧汝静
Luo Qian;Gao Chu;Zeng Jie;Zhu Li-na;Ou Ru-jing(The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou 510700;Guangzhou Medical University,Guangzhou 511436)
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2021年第9期891-896,I0002,共7页
Chinese Journal of Antibiotics
关键词
抗菌药物
ADR
皮试阳性
回顾性分析
Antibacterial drugs
ADR
Positive skin test
Retrospective analysis
