摘要
目的:探讨程序性死亡配体1(PD-L1)在结直肠癌组织中的表达及与患者生存期的关系。方法:采用免疫组织化学法(IHC)分别检测手术切除的100例结直肠癌组织及其对应的20例癌旁组织中PD-L1的表达情况,并分析其与患者生存预后的相关性。结果:PD-L1在结直肠癌组织中的阳性表达率为40.00%,癌旁组织为15.00%。Kaplan-Meier生存分析显示,PD-L1阳性者的总生存期(OS)较阴性者缩短(P=0.000);以淋巴结转移数目和TNM分期进行分组,发现N0和Ⅱ期亚组中PD-L1阳性者的OS均低于阴性者(P=0.000)。结论:PD-L1在结直肠癌组织中的表达高于癌旁组织,并与患者的生存预后密切相关,提示PD-L1有望成为判断结直肠癌预后的新标志物。
Objective:To investigate the relationship of programmed death-ligand 1(PD-L1)expression and the survival of patients with colorectal carcinoma(CRC).Methods:PD-L1 expression was detected in the postoperative CRC tissues from 100 patients together with the adjacent normal tissues in 20 of the 100 patients using immunohistochemistry(IHC),and the correlation of PD-L1 expression with the prognosis was analyzed.Results:The positive-expression rate of PD-L1 in CRC tissues was 40.00%,and 15.00%in the adjacent normal tissues.Kaplan-Meier survival analysis showed that the overall survival(OS)was significantly shorter in patients with positive PD-L1than in those with negative PD-L1(P=0.000).Subgrouping by the number of lymph node metastasis and TNM stage revealed that the OS was shorter in patients with positive PD-L1 in the N0 and II stage subgroups than in those with negative PD-L1(P=0.000).Conclusion:PD-L1 was highly expressed in CRC tissues compared to the adjacent normal tissues,and strongly correlated with the survival of such patients.The findings suggest PD-L1 can be a new marker for estimating the prognosis of patients with CRC.
作者
潘杨
王胜男
王臣慈
盛莉莉
谷生丽
PAN Yang;WANG Shengnan;WANG Chenci;SHENG Lili;GU Shengli(Department of Oncology,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2021年第5期430-433,共4页
Journal of Wannan Medical College
基金
皖南医学院重点基金项目(WK2020ZF17)
北京康盟慈善基金会医学科研发展基金项目(YXKY-TB206002)。
关键词
结直肠癌
程序性死亡配体1
预后
colorectal carcinoma
programmed death-ligand 1
prognosis
