摘要
采用大孔吸附树脂、Sephadex LH-20凝胶、ODS、硅胶和半制备高效液相等多种色谱分离方法研究紫珠属植物裸花紫珠的化学成分,从裸花紫珠65%乙醇提取物中分离得到10个化合物。根据MS、NMR、旋光度等分析技术鉴定出这10个化学成分分别为2个二萜:callicapene M6(1)、sterebin A(2);2个黄酮:木犀草素-7-O-新橙皮苷(5)、芹菜素-7-O-β-D-新橙皮苷(6);6个苯乙醇苷:异角胡麻苷(3)、crenatoside(4)、异毛蕊花糖苷(7)、毛蕊花糖苷(8)、(7R)-campneoside I(9)、(7S)-campneoside I(10)。其中化合物1为新化合物,化合物2、4首次从紫珠属中分离得到,化合物9、10首次从该植物中分离得到。
The purpose of the research is to study the bioactive constituents of Callicarpa nudiflora. From the 65% ethanol extract of C. nudiflora leaves, ten compounds were isolated by macroporous adsorption resin, Sephadex LH-20, ODS, silica gel, and preparative HPLC. These compounds were identified as callicapene M6(1), sterebin A(2), isomartynoside(3), crenatoside(4), luteolin-7-O-neohesperidoside(5), apigenin-7-O-β-D-neohesperidoside(6), isoacteoside(7), acteoside(8),(7R)-campneoside I(9), and(7S)-campneoside I(10) on the basis of NMR, HR-ESI-MS, and optical rotation data. Compound 1 was obtained as a new compound. Compounds 2 and 4 were isolated from the genus Callicarpa for the first time. Compounds 9 and 10 were isolated from C. nudiflora for the first time.
作者
占丽丽
黄伟明
卞玉婷
李诒光
陈杰
刘佳
邵坚
ZHAN Li-li;HUANG Wei-ming;BIAN Yu-ting;LI Yi-guang;CHEN Jie;LIU Jia;SHAO Jian(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Jiangzhong Pharmaceutical Co.,Ltd.,Nanchang 330004,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第16期4139-4144,共6页
China Journal of Chinese Materia Medica
基金
江西省教育厅科技项目(150876)。
关键词
裸花紫珠
二萜
苯乙醇苷
化学成分
Callicarpa nudiflora
diterpenoids
phenylethanoid glycosides
chemical constituents
