摘要
目的探讨Dixon IP/OP序列评估肝纤维化大鼠脂肪、铁质病理分级的价值。方法36只不同肝纤维化分期模型大鼠进行双Dixon IP/OP序列扫描,分析大鼠肝脏图像,观察信号强度并计算脂变指数(FI)、肝脏相对信号强度值(RSI),扫描完成后进行肝纤维化分期、脂肪及铁质病理分级。结果36只肝纤维化大鼠中,与同相位图像比较,反相位图像中8只呈低信号(22%),10只呈稍低信号(28%),18只呈等信号(50%)。脂肪病理分级0级6只(17.0%),1级9只(25.0%),2级13只(36.0%),3级8只(22.0%)。铁质病理分级0级9只(25.0%),1级10只(28.0%),2级9只(25.0%),3级4只(11.0%),4级4只(11.0%)。FI与脂肪病理分级存在相关性(rs=0.570,P<0.05),不同脂肪病理分级FI存在明显差异(P<0.05)。RSI与铁质病理分级存在相关性(rs=0.496,P<0.05),不同铁质病理分级RSI存在明显差异(P<0.05)。FI、RSI不受肝纤维化分期的影响(P>0.05)。FI对鉴别脂肪沉积的存在[曲线下面积(AUC)=0.922(0.880,0.997)]、评估重度脂肪沉积[AUC=0.844(0.696,0.992)]效果较好;RSI适用于评估铁质病理分级大于或等于3级的铁质沉积[AUC=0.902(0.802,1.000)]。结论Dixon IP/OP序列能够一定程度评估肝纤维化大鼠脂肪、铁质病理分级。
Objective To explore the value of Dixon IP/OP sequence in assessing steatosis and iron pathological grade in rats with liver fibrosis.Methods A total of 36 different stages of liver fibrosis model rats were scanned with dual Dixon IP/OP sequence,the rat liver images were analyzed,the signal intensity was observed,and fat index(FI)and relative signal intensity values(RSI)were calculated.Liver fibrosis staging,steatosis and iron pathological grade were performed after the scan was completed.Results Hypointense,slight hypointense and isointense found on out-of-phase images was 8 cases(22%),10 cases(28%)and 18 cases(50%),respectively.Steatosis pathological grade 0,1,2 and 3 was 6 cases(17.0%),9 cases(25.0%),13 cases(36.0%)and 8 cases(22.0%),respectively.Iron pathological grade 0,1,2,3 and 4 was 9 cases(25.0%),10 cases(28.0%),9 cases(25.0%),4 cases(11.0%)and 4 cases(11.0%),respectively.There was a correlation between FI and steatosis pathological grade(rs=0.570,P<0.05),and there was significant difference in FI with different steatosis pathological grades(P<0.05).There was a correlation between RSI and iron pathology grade(rs=0.496,P<0.05),and there was significant difference in RSI with different iron pathology grade(P<0.05).FI and RSI values were not affected by the stages of liver fibrosis(P>0.05).FI was effective in identifying the presence of fatty deposits[area under the curve(AUC)=0.922(0.880,0.997)]and heavy fatty deposits[AUC=0.844(0.696,0.992)];RSI was suitable for assessing iron deposition with iron pathological grade≥3[AUC=0.902(0.802,1.000)].Conclusion Dixon IP/OP sequence could assess steatosis and iron pathological grade in rats with liver fibrosis.
作者
金明丽
潘志华
舒健
王小凤
JIN Mingli;PAN Zhihua;SHU Jian;WANG Xiaofeng(Department of Radiology,the Second Affiliated Hospital of Chengdu Medical College/Nuclear Corporation 416 Hospital,Chengdu,Sichuan 610000,China;Department of Radiology,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)
出处
《重庆医学》
CAS
2021年第18期3090-3094,共5页
Chongqing medicine
基金
四川省卫生和计划生育委员会科研课题(17PJ436)。
