摘要
色酮化合物因其独特的骨架结构在抗肿瘤、抗菌和抗炎等方面表现出很强的药物活性.以CU(0Ac)_(2)为催化剂,CF_(3)SO_(2)Na为三氟甲基自由基源,过氧化叔丁醇(TBHP)为氧化剂,2-羟基苯基烯胺酮经自由基加成串联环化反应合成了3-三氟甲基色酮.反应条件温和,烯胺酮底物具有良好的普适性.
Chromones have shown strong drug activity in anti-tumor,antibacterial and anti-inflammatory aspects for their unique skeleton structure.Using Cu(OAc)_(2) as catalyst,CF_(3)SO_(2)Na as trifluoromethyl radical source,tert-butanol peroxide(TBHP)as oxidant,3-trifluoromethylchromone was synthesized by radical addition tandem cyclization reaction of 2-hydroxy-phenyl enaminone under mild reaction conditions,and enaminone substrate has good functional tolerance.
作者
杜科莹
张展铭
盛卫坚
Du Keying;Zhang Zhanming;Sheng Weijian(College of Chemical Engineerings Zhejiang University of Technology,Hangzhou 310014)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第8期3242-3248,共7页
Chinese Journal of Organic Chemistry
关键词
自由基加成
三氟甲基
烯胺酮
色酮
radical addition
trifluoromethyl
enaminone
chromones
