摘要
目的以高龄患者为研究对象,探究比较应用枸橼酸舒芬太尼注射液、依托咪酯乳状注射液不同药物麻醉的麻醉效果、术后应激反应和认知功能情况。方法选取2017年1月—2020年1月该院接收的行手术治疗的高龄患者52例为对象,根据麻醉药物应用不同分为A组、B组,各26例。A组患者予以枸橼酸舒芬太尼注射液麻醉,B组患者予以依托咪酯乳状注射液麻醉。观察并比较两组患者手术前后简单智力状态检查量表(MMSE)评分,手术前后不同时段皮质醇、去甲肾上腺素和肾上腺素水平,患者出院后恢复情况。结果术后6 h、2 d时段,A组患者MMSE评分低于B组,差异有统计学意义(t=2.317、3.221,P<0.05)。术后0 h、24 h时段,A组患者皮质醇、去甲肾上腺素和肾上腺素水平均高于B组,差异有统计学意义(t=2.762、7.278、2.136、2.371、2.051、2.161,P<0.05)。术后对患者进行为期6个月随访观察发现,A组患者出院后恢复良好率是88.46%,与B组的96.15%相比,差异无统计学意义(χ^(2)=0.271,P>0.05)。结论对高龄患者行麻醉药物诱导时,相比枸橼酸舒芬太尼注射液,依托咪酯乳状注射液的麻醉效果更佳,有助于患者认知功能提升,减少术后应激反应发生,降低患者术后不适感。
Objective To investigate and compare the anesthesia effect,postoperative stress response and cognitive function of sufentanil citrate injection and etomidate emulsion injection with different drugs in elderly patients.Methods Fifty-two elderly patients undergoing surgical treatment received in the hospital from January 2017 to January 2020 were selected as subjects.According to the application of anesthetics,they were divided into group A and group B,with 26 cases in each group.Patients in group A were anesthetized with sufentanil citrate injection,and patients in group B were anesthetized with etomidate emulsion injection.Observed and compared the Mini mental state examination(MMSE)scores of the two groups of patients before and after the operation,the levels of cortisol,norepinephrine and epinephrine at different periods before and after the operation,and the recovery of the patients after discharge.Results At 6 h and 2 d after operation,the MMSE score of group A was lower than that of group B,and the difference was statistically significant(t=2.317,3.221,P<0.05).At 0 h and 24 h after surgery,the levels of cortisol,norepinephrine and epinephrine in group A were higher than those in group B,and the difference was statistically significant(t=2.762,7.278,2.136,2.371,2.051,2.161,P<0.05).After a 6-month follow-up observation of the patients,it was found that the recovery rate of patients in group A was 88.46%after discharge,compared with 96.15%in group B,there was no statistically significant difference(χ^(2)=0.271,P>0.05).Conclusion Compared with sufentanil citrate injection,etomidate emulsion injection has a better anesthetic effect when induction of anesthetic drugs for elderly patients,which can help patients to improve their cognitive function and reduce postoperative stress reaction,reduce the patient’s postoperative discomfort.
作者
李燕
LI Yan(Department of Anesthesiology,Fengxian Hospital of Traditional Chinese Medicine,Fengxian,Jiangsu Province,221700 China)
出处
《系统医学》
2021年第16期16-18,71,共4页
Systems Medicine
关键词
认知功能
术后应激反应
麻醉效果
枸橼酸舒芬太尼注射液
依托咪酯乳状注射液
Cognitive function
Postoperative stress response
Anesthetic effect
Sufentanil citrate injection
Etomidate emulsion injection
