摘要
目的观察N-乙酰半胱氨酸(NAC)联合复方甲氧那明治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果,探讨药物间的交互作用。方法将96例AECOPD患者按2×2析因设计分为组1、组2、组3和组4,每组24例。其中2因素指药物NAC和复方甲氧那明;给药水平为1和0,其中1代表给药,0代表不给药。组1给予NAC联合复方甲氧那明治疗;组2给予NAC治疗;组3给予复方甲氧那明治疗;组4给予常规治疗。比较四组的治疗效果。结果组1的治疗总有效率为83.33%,明显高于组2、组3的50.00%和54.17%,差异具有统计学意义(P<0.05)。四组的不良反应总发生率无显著差异(P>0.05)。治疗后,组1的肺功能指标、血气分析指标均优于组2、组3,尤其FEV1%、SpO2的改善幅度较大(P<0.01);组1的CAT评分优于组2、组3,但mMRC评分却略逊于后者。结论NAC联合复方甲氧那明是治疗AECOPD患者的有效手段,药物交互作用明显,对改善临床症状和提高疗效有较大意义,值得临床应用推广。
Objective To observe the clinical effect of N-acetylcysteine(NAC)combined with compound methoxyphenamine in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and to explore the interaction between drugs.Methods Ninety-six patients with AECOPD were divided into group 1,group 2,group 3 and group 4 according to 2×2 factorial design,with 24 cass in each group.Among them,2 factors refer to the drug NAC and compound methoxyphenamine;the administration levels was designed to be 1 and 0,with 1 for administration and 0 for no administration.The group 1 was treated with NAC combined with compound methoxyphenamine;the group 2 was treated with NAC;the group 3 was treated with compound methoxyphenamine;the group 4 was given routine treatment.The therapeutic effects of the four groups were compared.Results The total effective rate of treatment in the group 1 was 83.33%,which were significantly higher than 50.00%and 54.17%in the group 2 and the group 3 respectively,and the differences were statistically significant(P<0.05).There were no significant differences in the total incidence of adverse reactions among the four groups(P>0.05).After treatment,the indexes of pulmonary function and blood gas analysis in the group 1 were better than those in the group 2 and the group 3,especially FEV1%and SpO2 has the greatest improvement(P<0.01);the CAT score of the group 1 was better than that of the group 2 and the group 3,but the mMRC score was slightly inferior to the latter.Conclusion NAC combined with compound methoxyphenamine is an effective method for the treatment of AECOPD patients.The drug interaction is obvious,which is of great significance to improve clinical symptoms and curative effect,and is worthy of clinical application and promotion.
作者
刘露
董健
LIU Lu;DONG Jian(Respiratory and Critical Care Medicine Department,Jiangbei Branch of Wuhan Union Hospital,Wuhan 430100,China)
出处
《临床医学研究与实践》
2021年第27期33-35,共3页
Clinical Research and Practice
