摘要
目的以双能X线骨密度(DEX)测定为诊断骨质疏松症的金标准,评价IOF骨质疏松风险一分钟测试题(IOF)、定量超声骨密度(QUS-T)诊断骨质疏松症(OP)的切点值及单独或联合运用筛查骨质疏松症的诊断价值,以期找到更为行之有效的骨质疏松症筛查工具,为该人群骨质疏松症的早期诊断提供参考和依据。方法选取400名成都社区绝经后妇女和年龄大于50岁的男性为研究对象,设计问卷调查表,收集受试者基本人口学资料、病史资料、骨质疏松症相关危险因素,并对400名受试者进行IOF骨质疏松风险一分钟测试题、定量超声骨密度测定及双能X线骨密度(DEX)测定。结果单独运用IOF、QUS-T作为筛查标准时ROC曲线下面积分别是0.676、0.832,切点值分别是:6.5、-2.75,其约登指数分别是0.278、0.527,具有一定的诊断价值;IOF联合QUS-T作为筛查标准时,ROC曲线下面积是0.834,以Y=23.196,此时灵敏度为64.8%,特异性为91.1%,约登指数为0.559;QUS-T与IOF并联时即满足IOF≥6.5或QUS-T≤-2.75其中之一即可诊断为骨质疏松症,其灵敏度为77.84%,特异性为76.79%,约登指数为0.546;串联即同时满足IOF≥6.5和QUS-T≤-2.75即诊断为骨质疏松症,其灵敏度为29.55%,特异性为96.43%,约登指数为0.260,具有较高的诊断价值。结论单独或联合运用IOF骨质疏松风险一分钟测试题、定量超声骨密度筛查骨质疏松症具有一定的诊断价值,但仍有待进一步验证。
Objective To evaluate the the diagnostic value of IOF one-minute risk test combined with quantitative ultrasound screening for the diagnosis of osteoporosis.Methods Four hundred postmenopausal women and men older than 50 years old were selected as the research subjects.A questionnaire was designed.Data of population,disease history,and osteoporosis-related risk factors of the subjects were collected.IOF one-minute osteoporosis risk test(IOF),quantitative ultrasound(QUS-T),and dual-energy X-ray absorptiometry(DEX)were examined.Results When IOF and QUS-T were used as the screening criteria alone,the area under the ROC curve was 0.676 and 0.832,and the cut-off point was 6.5 and-2.75,and the Yoden indexes were 0.278 and 0.527,respectively.When IOF combined with QUS-T was used as the screening standard,the area under the ROC curve was 0.834,with Y=23.196,and the sensitivity and specificity were 64.8%and 91.1%,respectively.When osteoporosis was diagnosed either with IOF≥6.5 or with QUS-T≤-2.75,the sensitivity was 77.84%,the specificity was 62.05%,and the Yoden index was 0.5463.When osteoporosis was diagnosed together with IOF≥6.5 and QUS-T≤-2.75,the sensitivity was 29.55%,the specificity was 96.43%,and the Yoden index was 0.2598.Conclusion The use of IOF and QUS-T alone or in combination to screen for osteoporosis has a certain diagnostic value,but it still needs further verification.
作者
杨帆
蒋小波
曹洪义
宁蓬
冯秋
曾静
陈敏
刘虹蝶
万海艳
陈应辉
YANG Fan;JIANG Xiaobo;CAO Hongyi;NING Peng;FENG Qiu;ZENG Jing;CHEN Min;LIU Hongdie;WAN Haiyan;CHEN Yinghui(Department of Endocrinology and Metabolism,Chengdu Fifth People’s Hospital,Chengdu 611130;Department of Heart and Blood Vessel Internal Medicine,Chengdu Fifth People's Hospital,Chengdu 611130,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2021年第9期1339-1342,1360,共5页
Chinese Journal of Osteoporosis
基金
四川省卫生与计划生育委员会科研项目(18PJ352)。
