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肺心病患者肺部感染的病原菌分布特征及IL-6基因-572C/G多态性的研究

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摘要 目的探讨肺心病患者肺部感染的病原菌分布特征,分析IL-6基因-572C/G多态性与肺部感染的相关性。方法将80例肺心病住院患者根据是否合并肺部感染分为肺部感染组(n=31)和非感染组(n=49)。对感染组的痰液样本进行细菌鉴定及药敏试验。检测两组的血清IL-6水平及IL-6基因-572C/G多态性。结果肺部感染组共检出病原菌46株,其中,革兰阴性菌32株(69.57%),主要为铜绿假单胞菌;革兰阳性菌14株(30.43%),主要为金黄色葡萄球菌;铜绿假单胞菌对左氧氟沙星最耐药、对亚胺培南最敏感,金黄色葡萄球菌对青霉素G最耐药、对万古霉素最敏感;肺部感染组的血清IL-6水平显著高于非感染组(P<0.05);两组的CC、CG、GG基因型频率比较无差异(P>0.05);两组的C/G等位基因频率比较无差异(P>0.05)。结论本院肺心病合并肺部感染以革兰阴性菌为主,对抗菌药物表现不同程度耐药性,应结合药敏试验结果选择抗菌药物治疗。IL-6基因启动子区-572C/G基因多态性可能与肺心病患者肺部感染易感性无关。
出处 《贵州医药》 CAS 2021年第9期1368-1370,共3页 Guizhou Medical Journal
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