摘要
目的研究冠状动脉粥样硬化性心脏病(冠心病)患者血清内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、视黄醇结合蛋白4(RBP4)、趋化素(Chemerin)水平与炎性因子及冠状动脉病变支数的关系。方法选择2018年2月—2020年2月本院收治的冠心病患者124例作为病变组,另取同期本健康体检者100名作为对照组。检测并比较两组血清Vaspin、RBP4、Chemerin水平与炎性因子水平。将病变组患者按照病变支数的差异分作单支病变70例、双支病变36例以及多支病变18例,比较三组患者血清Vaspin、RBP4、Chemerin水平与炎性因子水平。采用Pearson相关性分析冠心病患者血清Vaspin、RBP4、Chemerin水平与炎性因子水平及病变支数的关系。通过受试者工作特征(ROC)曲线分析血清Vaspin、RBP4、Chemerin诊断冠心病的效能。结果病变组血清Vaspin、白细胞介素-10(IL-10)水平明显低于对照组,而RBP4、Chemerin以及C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均明显高于对照组(P<0.05)。双支病变、多支病变患者的血清Vaspin、IL-10水平均低于单支病变患者,且多支病变患者低于双支病变患者(P<0.05);双支病变、多支病变患者的血清RBP4、Chemerin以及CRP、IL-6水平均高于单支病变患者,且多支病变患高于双支病变患者(P<0.05)。经Pearson相关性分析可得:冠心病患者血清Vaspin水平与血清CRP、IL-6水平及病变支数均呈负相关,与血清IL-10水平呈正相关(P<0.05);血清RBP4、Chemerin水平与血清CRP、IL-6水平及病变支数均呈正相关,与血清IL-10水平呈负相关(P<0.05)。经ROC曲线分析可得:血清Vaspin、RBP4、Chemerin联合诊断冠心病的曲线下面积、敏感度以及特异度均高于上述三项指标单独检测。结论冠心病患者血清Vaspin水平明显降低,而RBP4、Chemerin水平明显升高,且上述三项血清学指标均和冠心病患者炎性因子水平及病变支数密切相关。
Objective To investigate the relationship between the levels of visceral adipose tissue-derived serine protease inhibitor(Vaspin),retinol binding protein 4(RBP4),and Chemerin in serum and inflammatory factors and the number of coronary artery lesions in patients with coronary atherosclerotic heart disease.Methods 124 patients with coronary artery disease who were admitted to the affiliated hospital of Wanxi health vocational college from February 2018 to February 2020 were included in the study,which were labeled as the pathological group.In addition,100 healthy people who underwent physical examination in affiliated hospital of Wanxi health vocational college during the same period were selected as the control group.Serum Vaspin,RBP4,Chemerin and inflammatory factors levels were detected and compared between the two groups.According to the difference in the number of lesions,the patients in the lesion group were divided into single-vessel lesions(70 cases),double-vessel lesions(36 cases)and multiple-vessel lesions(18 cases),and the Vaspin,RBP4 and Chemerin levels and inflammatory factors levels in the three groups were compared.Pearson correlation analysis was used to determine the relationship between serum Vaspin,RBP4 and Chemerin levels and inflammatory factors and the number of lesions in patients with coronary artery disease.The efficacy of serum Vaspin,RBP4 and Chemerin in diagnosing coronary artery disease were analyzed by receiver operating characteristic(ROC)curve analysis.Results The serum levels of Vaspin and interleukin-10(IL-10)in the pathological group were significantly lower than those in the control group,while the levels of RBP4,Chemerin,C-reactive protein(CRP)and interleukin-6(IL-6)were significantly higher than those in the control group(P<0.05).Serum Vaspin and IL-10 levels in patients with double-vessel disease and multi-vessel disease were lower than those in patients with single-vessel disease,and patients with multi-vessel disease were lower than those in patients with double-vessel dise
作者
张莉
薛礼
张磊
王艳梅
Zhang Li(Clinical medicine faculty,Wanxi health vocational college,Lu'an,Anhui,237005,China)
出处
《齐齐哈尔医学院学报》
2021年第15期1289-1293,共5页
Journal of Qiqihar Medical University
基金
安徽省高等学校自然科学研究项目(编号:KJ2018A0959)。
