摘要
目的:采用CT灌注成像技术评价NP化疗联合鸦胆子油乳治疗非小细胞肺癌的临床应用价值。方法:回顾性分析河北北方学院附属第一医院2017年1月至2018年12月收治的40例非小细胞肺癌患者的影像资料,根据治疗方案分为观察组(n=20)和对照组(n=20),对照组采用常规NP化疗方案,21d为1个治疗周期,连续完成3个周期治疗,观察组同时静脉滴注鸦胆子油乳30mL+0.9%氯化钠注射液250mL,1次/d,连续治疗28d为1周期,连续完成3个周期治疗;采用TOSHIBA Aquilion One 320排CT扫描仪于治疗前及治疗3个周期后,分别对两组患者进行肺部常规CT扫描及目标病灶灌注扫描,记录治疗前、后病灶大小变化、灌注参数值:血流量(BF)、血容量(BV)、平均通过时间(MTT)、毛细血管渗透性(PS)的组间差异。结果:治疗3个周期后,观察组缓解率为60%(12/20),对照组缓解率为45%(9/20),观察组缓解率高于对照组(60.0%∶45.0%),差异无统计学意义(P=0.342);治疗后,两组BV、BF水平均降低,差异具有统计学意义(P<0.05),两组MTT水平均升高,差异具有统计学意义(P<0.05),治疗后两组PS水平均降低,且观察组低于对照组,但差异无统计学意义(P>0.05)。结论:鸦胆子油乳辅助治疗肺癌安全有效,能够抑制肿瘤细胞增殖,改善肿瘤组织的微循环,提高机体免疫功能,而CT灌注成像能敏感地反映肺癌病灶血流动力学变化,为肺癌的疗效评估提供客观的功能影像学依据。
Objective:To evaluate the clinical application value of NP chemotherapy combined with Brucea javanica oil emulsion in the treatment of non-small cell lung cancer using CT perfusion imaging technology.Methods:The imaging data of 40 patients with non-small cell lung cancer admitted to the First Affiliated Hospital of Hebei North University from January 2017 to December 2018 were retrospectively analyzed.According to the treatment plan,they were divided into observation group(n=20)and control group(n=20).The control group was treated with conventional NP chemotherapy during 3 consecutive treatment cycles,21 days in a cycle.The observation group was given intravenous drip of Brucea javanica oil emulsion 30ml and 0.9%sodium chloride injection 250ml in the same perion,2 times/day,28 days in a cycle,for 3 consecutive cycles of treatment.TOSHIBA Aquilion One 320-row CT scanner was used for conventional lung CT scan and Target lesion perfusion scan before and after 3 cycles of treatment,and data were recorded,including the changes in lesion size before and after treatment,perfusion parameter values:blood flow(BF),blood volume(BV),mean transit time(MTT),capillary permeability(PS)between groups.Results:After 3 cycles of treatment,the remission rate of the observation group was 60%(12/20),and the remission rate of the control group was 45%(9/20).The remission rate of the observation group was higher than that of the control group(60.0%∶45.0%).The difference was not statistically significant(χ^(2)=0.902,P=0.342);after treatment,the BV and BF levels of the two groups decreased,and the observation group was lower than the control group(P<0.05),the MTT levels of the two groups increased(P<0.05);PS levels in the two groups decreased after treatment,and the observation group was lower than the control group,but the difference was not statistically significant(P>0.05).Conclusion:Brucea javanica oil emulsion is safe and effective in adjuvant treatment of lung cancer.It can inhibit the proliferation of tumor cells,improve the micr
作者
李传贵
刘晓城
张新慧
周桂娟
朱月香
LI Chuangui;LIU Xiaocheng;ZHANG Xinhui(The First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China)
出处
《河北医学》
CAS
2021年第9期1508-1512,共5页
Hebei Medicine
基金
河北省张家口市重点研发计划项目,(编号:1921129H)。
关键词
非小细胞肺癌
NP方案化疗
鸦胆子油乳
CT灌注成像
Non-small cell lung cancer
NP chemotherapy
Brucea javanica oil emulsion
CT Perfusion Imaging