摘要
To evaluate the effects of different extract of Pseudostellaria heterophylla on immunological function in mice based on Meta-analysis and Network meta-analysis,the article retrieved domestic and foreign databases according to the"PICO"retrieval strategy,and used Stata and ADDIS software for Meta analysis.A total of 6 reports,10 randomised controlled trials(RCTs)were eventually involved.Meta analysis results showed that:compared with the control group,the experimental group of polysaccharide,saponin and crude extract were better than that of the control(P<0.05),which significantly improved the immunological function in mice.Network meta-analysis results showed that the saponin had the best effect on the increase of phagocytic index and the differences were statistically significant[MD=1.50,95%CI(0.71,2.28),P<0.05];The polysaccharide and saponin had better effect on the increase of spleen index than the control and crude extract,and the differences were statistically significant[MD=0.77,95%CI(0.27,1.31),P<0.05],[MD=0.71,95%CI(0.01,1.50),P<0.05];the polysaccharide had the best effect on the increase of thymus index and the differences were statistically significant[MD=0.70,95%CI(0.11,1.34),P<0.05].The rank probability showed that the saponin of Pseudostellaria heterophylla had the maximum probability to increase phagocytic index of mice;the probability for the components of Pseudostellaria heterophylla increasing spleen index of mice was in the order of crude extract>polysaccharide>saponin;the probability for the components of Pseudostellaria heterophylla increasing thymus index of mice was in the order of saponin>polysaccharide>crude extract.Based on the available evidence,the extract of Pseudostellaria heterophylla could improve the immunity of mice,and the clinical effect of polysaccharide and saponin was the best,which provided a more valuable scientific reference for evidencing that the polysaccharide and saponin of Pseudostellaria heterophylla was the effective components for improving immunological function,a
采用Meta分析和网状Meta分析方法评价不同太子参提取组分对小鼠机体免疫功能的影响及其效力差异。文章采用“PICO”检索策略检索国内外数据库,采用Stata、ADDIS软件考察指标的Meta分析。结果共纳入6篇文献10项随机对照试验(RCTs)。Meta分析显示太子参多糖、皂苷和粗提取物对小鼠机体免疫力水平均有提高作用(P<0.05);网状Meta分析显示:太子参皂苷对提高小鼠吞噬指数具有最优效果且差异具有统计学意义[MD=1.50,95%CI(0.71,2.28),P<0.05];太子参多糖、皂苷提高小鼠免疫器官脾脏指数均优于空白对照组和太子参粗提取物组,且差异具有统计学意义[MD=0.77,95%CI(0.27,1.31),P<0.05],[MD=0.71,95%CI(0.01,1.50),P<0.05]。太子参多糖对提高小鼠免疫器官胸腺指数具有最优效果且差异具有统计学意义[MD=0.70,95%CI(0.11,1.34),P<0.05]。排序概率图显示太子参皂苷提高小鼠吞噬指数的概率最大;太子参组分提高小鼠免疫器官脾脏指数的概率由大到小为:粗提取物>多糖>皂苷;太子参组分提高小鼠免疫器官胸腺指数的概率由大到小为:皂苷>多糖>粗提取物。基于现有文献显示太子参组分可提高小鼠免疫力,且太子参多糖和皂苷临床表现效力最佳,为循证太子参多糖和皂苷是提高机体免疫功能的有效组分提供依据,更为其进一步精准开发太子参中药资源提供借鉴。
基金
福建省科技计划引导性项目(2019Y6005)
福建省科学技术厅创新资金项目(2018C0041)
校企合作横向课题(104/KH180151A)
福建省特色药用植物工程技术研究中心开放基金项目(PP202003)。
