摘要
目的探讨转移性肺大细胞神经内分泌癌(LCNEC)的临床特征及预后相关因素。方法检索SEER数据库中2010—2018年诊断为转移性LCNEC的患者信息,分析其临床特征及预后。结果纳入的513例患者中,男293例(57.1%),女220例(42.9%);年龄<65岁242例(47.2%),年龄≥65岁271例(52.8%);原发病变位于肺上叶246例(48%);原发肿瘤直径0~21.3 cm,直径<5 cm 229例(44.6%);初诊时骨转移173例(33.7%)、脑转移172例(33.5%)、肝转移178例(34.7%)、肺转移95例(18.5%)、淋巴结转移380例(74%);生存时间0~94个月,中位生存期4个月;1 a生存率22.4%,2 a生存率8.5%。单因素分析显示,年龄<65岁、无骨、肝、淋巴结转移患者的总生存期(OS)更长(P<0.05)。多因素分析显示,年龄≥65岁、骨、肝转移是转移性LCNEC预后的独立危险因素(P<0.05)。结论转移性LCNEC预后差,多见于老年男性,年龄≥65岁、骨、肝转移是转移性LCNEC预后的危险因素。
Objective To investigate the clinical features and prognostic factors of metastatic pulmonary large cell neuroendocrine carcinoma(LCNEC).Methods The information of patients diagnosed with metastatic LCNEC from 2010 to 2018 in SEER database was retrieved,and research the clinical features and the survival influence factors of these patients.Results Among the 513 patients included,293(57.1%)were males,220(42.9%)were females,242(47.2%)were younger than 65 years old,and 271(52.8%)were older than 65 years old.The primary lesion was mostly located in the upper lobe of the lung in 246(48%)patients.The primary tumor diameter ranged from 0 to 21.3 cm,and 229(44.6%)patients had the primary tumor diameter<5 cm.At initial diagnosis,173(33.7%)patients had bone metastasis,172(33.5%)patients had brain metastasis,178(34.7%)patients had liver metastasis,95(18.5%)patients had intrapulmonary metastasis,and 380(74.0%)patients had lymph node metastasis.The survival time of all patients ranged from 0 to 94 months,with a median survival time of 4 months.The 1 a and 2 a survival rates were 22.4%and 8.5%respectively.Univariate analysis shows that the age at diagnosis<65 years old,without bone metastasis,without liver metastasis,without lymph node metastasis are associated with longer overall survival(OS)(P<0.05).Multivariate analysis showed that age at diagnosis≥65 years old,with bone metastasis and liver metastasis are independent risk factors for prognosis of metastatic LCNEC.Conclusion Metastatic pulmonary large cell neuroendocrine carcinoma,which is more common in elderly men,has a poor prognosis.Age of diagnosis≥65 years old,with bone metastasis and liver metastasis are risk factors for prognosis of LCNEC patients.
作者
胡浩强
申淑景
李醒亚
HU Haoqiang;SHEN Shujing;LI Xingya(Department of Medical Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Tumor Radiotherapy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《河南医学研究》
CAS
2021年第26期4818-4822,共5页
Henan Medical Research
关键词
肺大细胞神经内分泌癌
肿瘤转移
临床特征
预后
pulmonary lung large cell neuroendocrine carcinoma
tumor metastasis
clinical features
prognosis
