摘要
肿瘤转移是恶性肿瘤最为重要的生物学特征之一,同时也是影响预后及导致治疗失败的主要因素。近年来研究表明,肿瘤微环境中的胞外基质(extracellular matrix,ECM)纤维生成在肿瘤转移过程中发挥极为关键的作用。肿瘤ECM纤维生成会形成相互交联的网状结构,这种网状结构不仅对肿瘤细胞起到支持和营养作用,同时对肿瘤的生长和浸润也起到相当重要的作用。因此,阻断肿瘤组织ECM纤维生成有可能对肿瘤转移产生抑制作用,这使得ECM纤维生成作为治疗靶标,备受人们关注。该文对肿瘤ECM纤维生成与肿瘤转移研究进展进行综述,并对靶向肿瘤ECM纤维生成进行肿瘤转移治疗的策略进行探讨,为后续研究及指导临床提供重要参考。
Tumor metastasis is one of the most important biologi-cal characteristics of malignant tumor, and it is also the main factor resulting in poor prognosis and leading to failure of treat-ment. In recent years, studies have shown that the extracellular matrix ( ECM) of tumor microenvironment plays a critical role in tumor metastasis. Tumor ECM fibrogenesis could form the cross-linked network structure, which not only provides nutrition and support to tumor, also it is necessary to tumor growth and inva-sion. These research results indicate that blocking ECM fibro-genesis may exert an inhibitory effect on tumor metastasis. Therefore, targeting ECM fibrogenesis has become a particularly attractive strategy as it can be used in the treatment of metasta-sis-related diseases. The ECM fibrogenesis in tumor is reviewed in this paper as well as the treatment strategies on tumor metas-tasis by targeting ECM fibrogenesis, which may provide refer-ences for follow-up research and clinical treatment.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2015年第11期1485-1488,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81173174
81202655
81403260)
中国博士后科学基金资助项目(No2014M551639)
江苏省博士后资助项目(No 1401138C)
江苏省自然科学基金资助项目(No BK2012854)
江苏省2014年度普通高校研究生科研创新计划项目(No KYZZ_0270)
2013年江苏高校优秀科技创新团队计划
江苏高校品牌专业建设工程资助项目(No PPZY2015A070)
江苏高校中药学优势学科建设工程资助项目(PAPD)
