摘要
目的探讨健脾化湿消脂汤治疗非酒精性脂肪性肝病的效果及对超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平的影响。方法将医院2020年1月—2020年11月收治的71例非酒精性脂肪性肝病患者按照随机数字表法分为两组,对照组35例给予多烯磷脂酰胆碱胶囊治疗,观察组36例在对照组基础上给予健脾化湿消脂汤治疗。观察两组患者临床疗效、血清因子水平、肝功能以及不良反应发生率。结果治疗后,观察组总有效率高于对照组(P<0.05);治疗前两组白细胞介素4(IL-4)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、同型半胱氨酸(Hcy)比较差异无统计学意义(P>0.05);治疗后,观察组IL-4高于对照组,hs-CRP、TNF-α、Hcy均低于对照组(P<0.05);治疗前两组丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBiL)以及谷氨酰转肽酶(GGT)比较差异无统计学意义(P>0.05);治疗后,观察组TBiL、AST、ALT、GGT均低于对照组(P<0.05);观察组不良反应发生率和对照组比较差异无统计学意义(P>0.05)。结论健脾化湿消脂汤通过调节非酒精性脂肪性肝病患者血清因子水平,改善肝功能,进而提高临床疗效且不增加不良反应发生率。
Objective To explore the effect of Jianpi Huashi Xiaozhi Decoction(健脾化湿消脂汤) on nonalcoholic fatty liver and its influence on the levels of high-sensitivity C-reactive protein(hs-CRP) and homocysteine(Hcy). Methods 71 patients with nonalcoholic fatty liver admitted to our hospital from January 2020 to November 2020 were randomly divided into two groups. The control group(35 cases) was treated with polyene phosphatidylcholine capsule, and the observation group(36 cases) was treated with Jianpi Huashi Xiaozhi Decoction on the basis of the control group. Clinical efficacy, serum factor level, liver function and incidence of adverse reactions were observed. Results After treatment, the total effective rate of observation group was higher than that of control group(P<0.05). Before treatment, there was no significant difference in IL-4, hs-CRP, TNF-α and Hcy between the two groups(P>0.05). After treatment, IL-4 in observation group was higher than that in control group, while hs-CRP, TNF-α and Hcy were lower than those in control group(P<0.05). There was no significant difference in alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBiL) and glutamyltranspeptidase(GGT) between the two groups before treatment(P>0.05). After treatment, TBiL, AST, ALT and GGT in observation group were lower than those in control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05). Conclusion Jianpi Huashi Xiaozhi Decoction can improve the liver function by regulating the serum factor level of patients with nonalcoholic fatty liver disease, thus improving the clinical efficacy and not increasing the incidence of adverse reactions.
作者
冉云
杨大国
胡世平
吕锦珍
陈文林
郑容
RAN Yun;YANG Daguo;HU Shiping;LYU Jinzhen;CHEN Wenlin;ZHENG Rong(Shenzhen Hospital,Beijing University of Chinese Medicine,Shenzhen 518172,Guangdong,China)
出处
《实用中医内科杂志》
2021年第8期93-96,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
广东省自然科学基金面上项目(2019A1515011555)
深圳市龙岗区科技创新局项目(LGKCYLWS20 19000808)
深圳市科技创新委员会项目(JCYJ20180302150218892)。
关键词
健脾化湿消脂汤
非酒精性脂肪性肝病
多烯磷脂酰胆碱
超敏C反应蛋白
Jianpi Huashi Xiaozhi Decoction(健脾化湿消脂汤)
Non-alcoholic fatty liver disease
Polyene phosphati-dylcholine
Hypersensitive C-reactive protein
