摘要
目的:探讨二甲双胍联合双歧杆菌三联活菌胶囊对非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)患者血清TNF-α及肝脂肪变的影响。方法:选取NAFLD患者84例。其中,对照组42例,予以二甲双胍治疗;治疗组42例,在二甲双胍基础上加用双歧杆菌三联活菌胶囊。疗程均为8周。治疗前及治疗8周后,所有患者进行肝脏CT检查,比较2组生化指标及肿瘤坏死因子(tumor necrosis factor-α,TNF-α)变化。结果:治疗8周后,与治疗前及对照组治疗后比较,治疗组体重指数(body mass index,BMI)、空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglobin,Hb A1C)、甘油三脂(triglyceride,TG)、胆固醇(cholesterol,TC)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)、TNF-α减低,治疗组总有效率显著高于对照组(P<0.05)。治疗组肝脂肪变的程度与BMI,HOMA-IR,TG,TC和TNF-α呈正相关(P<0.05)。结论:二甲双胍联合双歧杆菌三联活菌胶囊治疗NAFLD疗效明确,TNF-α水平降低,肝脏脂肪变程度减轻,疗效优于单用二甲双胍。
Objective： To investigate the effects of metformin combined with enteric bifid-triple viable capsule on the serum TNF-α and liver steatosis in nonalcoholic fatty liver disease. Methods： Patients with nonalcoholic fatty liver disease （n = 84） were randomly divided into two groups. They received routine treatment of diet, exercise and metformin for 8 weeks （control, n = 42） , or combined with enteric bifid-triple viable capsule for 8 weeks in addition to the routine treatment. Results： Body mass index （BMI）, fasting blood glucose （FBG）, glycosylated hemoglobin （ HbAlC ） , triglyceride （TG） , cholesterol （ TC ） , insulin resistance index （HOMA-IR） , and tumor necrosis factor-α （TNF-α） were significantly decreased after combined treatment compared with the val- ues of baseline and control group （P 〈0.05）. The total effective rate of the combination group （66.67%） was significantly higher than that of control group （40.48% , P 〈 0.05）. Correlation analysis showed that the degree of liver steatosis was positively correlated with BMI, HOMA-IR, TG, TC and TNF-α （P 〈 0.05）. Conclusion ： Metformin combined with enteric bifid-triple viable capsule is effective in the treatment of NAFLD. [
出处
《中国新药杂志》
CAS
CSCD
北大核心
2016年第4期439-442,446,共5页
Chinese Journal of New Drugs
