摘要
目的探讨颈动脉内膜中层厚度(CIMT)、踝臂指数(ABI)与牙周病患者冠脉病变程度的相关性。方法选取2018年2月至2019年12月武汉市汉口医院收治的180例牙周病患者作为研究对象,按照Gensini评分分为正常组(n=40,Gensini评分=0),A组(n=35,Gensini评分>0-36)、B组(n=37,Gensini评分>36-78)、C组(n=32,Gensini评分>78-117)及D组(n=36,Gensini评分>117-160)。比较各组患者CIMT、ABI及Gensini评分,采用Spearman法分析牙周病合并冠脉病变患者ABI、CIMT与Gensini评分的相关性关系,采用ROC曲线法分析ABI、CIMT及Gensini评分预测牙周病合并冠脉病变的临床价值。结果A组的ABI与正常组比较,差异无统计学意义(P>0.05),B、C、D组的ABI均小于正常组,CIMT与Gensini评分均大于正常组,差异具有统计学意义(P<0.05)。牙周病合并冠脉病变患者ABI与Gensini评分呈负相关(r=-0.602,P<0.05),CIMT与Gensini评分呈正相关(r=0.651,P<0.05)。ABI、CIMT单独检测预测牙周病合并冠脉病变的AUC、敏感性及特异性均低于Gensini评分,差异有统计学意义(P<0.05)。ABI联合CIMT检测预测牙周病合并冠脉病变的AUC、敏感性、特异性与Gensini评分比较,差异无统计学意义(P<0.05)。结论CIMT、ABI与牙周病患者冠脉病变程度存在密切相关性,ABI联合CIMT检测预测牙周病合并冠脉病变的临床价值与Gensini评分相似,具有较好的应用价值。
Objective To investigate the correlation between carotid intima-media thickness(CIMT),ankle-brachial index(ABI)and the degree of coronary artery disease in patients with periodontal disease.Methods A total of 180 patients with periodontal disease admitted to Hankou Hospital of Wuhan City from February 2018 to December 2019 were selected as the research objects.According to the Gensini scores,they were divided into normal group(n=40,Gensini score=0),group A(n=35,Gensini score>0-36),group B(n=37,Gensini score>36-78),group C(n=32,Gensini score>78-117)and group D(n=36,Gensini score>117-160).The CIMT,ABI,and Gensini scores of these group were compared.The Spearman method was used to analyze the correlation between ABI,CIMT,and Gensini scores in patients with periodontal disease and coronary artery disease.The ROC curve method was used to analyze ABI,CIMT and Gensini scores to predict the clinical value of coronary artery disease with periodontal disease.Results There was no statistically significant difference between the ABI of group A and the normal group(P>0.05),the ABI of groups B,C,and D were all lower than the normal group,and the CIMT and Gensini scores were higher than those of the normal group,and the difference was statistically significant(P<0.05).In patients with periodontal disease and coronary artery disease,ABI was negatively correlated with Gensini score(r=-0.602,P<0.05),and CIMT was positively correlated with Gensini score(r=0.651,P<0.05).The AUC,sensitivity and specificity for ABI,CIMT respectively predicting periodontal disease combined with coronary artery disease were lower compared with Gensini score,and the differences were statistically significant(P<0.05).There were no significant differences in AUC,sensitivity,specificity and Gensini score of ABI combined with CIMT in predicting periodontal disease with coronary artery disease(P<0.05).Conclusion CIMT and ABI are closely related to the degree of coronary artery disease in patients with periodontal disease.The clinical value of ABI combined wit
作者
张复兰
王圣男
金友仁
ZHANG Fu-lan;WANG Sheng-nan;JIN You-ren(Department of Stomatology,Hankou Hospital of Wuhan City,Hubei Province,Wuhan 430012,China)
出处
《中国当代医药》
CAS
2021年第26期191-194,F0003,共5页
China Modern Medicine
基金
湖北省武汉市医学科研项目(WX19Z24)。
关键词
牙周病
颈动脉内膜中层厚度
踝臂指数
冠脉病变
Periodontal disease
Carotid artery intima-media thickness
Ankle-brachial index
Coronary artery disease
