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评价静脉注射右美托咪定辅助全身麻醉的有效性和安全性 被引量:3

Evaluation on the Effectiveness and Safety of Intravenous Injection of Dexmedetomidine for General Anesthesia
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摘要 目的探讨对全身麻醉患者采取右美托咪定静脉注射进行辅助麻醉后获得效果以及安全性。方法方便选取该院2017年6月—2020年5月收治的58例全身麻醉患者,按数字奇偶法分组;麻醉组(29例):采用右美托咪定静脉注射完成辅助麻醉;对照组(29例):采用生理盐水静脉注射完成辅助麻醉;就组间收缩压、舒张压、心率、不良反应(寒战高热、恶心呕吐、苏醒躁动)情况、镇定评分展开对比。结果麻醉组全身麻醉患者收缩压、舒张压以及心率均低于对照组,差异有统计学意义(t=2.179、2.239、3.186,P<0.05);两组全身麻醉患者不良反应集中于寒战高热、恶心呕吐、苏醒躁动几方面;麻醉组全身麻醉患者总不良反应发生率(3.45%)低于对照组(41.38%),差异有统计学意义(χ^(2)=11.997,P<0.05);麻醉组全身麻醉患者麻醉5 min后镇定评分、麻醉15 min后镇定评分均高于对照组,差异有统计学意义(t=10.051、5.008,P<0.05)。结论右美托咪定静脉注射方式有效运用,可使全身麻醉患者辅助麻醉效果获得显著提升,将收缩压、舒张压、心率水平显著降低,将寒战高热、恶心呕吐、苏醒躁动不良反应显著减少,使镇定效果显著提升,最终实现全身麻醉患者有效预后。 Objective To investigate the effect and safety of dexmedetomidine for adjuvant anesthesia in patients with general anesthesia.Methods 58 patients with general anesthesia admitted to the hospital from June 2017 to May 2020 were convenient selected,and were divided into groups by digital parity;anesthesia group(29 cases):dexmedetomidine intravenous injection to complete auxiliary anesthesia;control group(29 cases):use normal saline intravenous injection to complete the auxiliary anesthesia;compare the systolic blood pressure,diastolic blood pressure,heart rate,adverse reactions(chills and fever,nausea and vomiting,restlessness),and calmness scores between groups.Results The systolic blood pressure,diastolic blood pressure and heart rate of the general anesthesia group in the anesthesia group were lower than those in the control group,and the difference was statistically significant(t=2.179,2.239,3.186,P<0.05);the adverse reactions of the two groups of general anesthesia patients were concentrated on chills,high fever,nausea and vomiting,and restlessness.In several aspects:the total incidence of adverse reaction rate of general anesthesia patients in the anesthesia group(3.45%)was lower than that of the control group(41.38%),and the difference was statistically significant(χ^(2)=11.997,P<0.05);the general anesthesia patients in the anesthesia group were sedated after 5 min of anesthesia,and sedated after 15 min of anesthesia scores were higher than those of the control group,and the difference was statistically significant(t=10.051,5.008,P<0.05).Conclusion The effective use of intravenous injection of dexmedetomidine can significantly improve the auxiliary anesthesia effect of patients with general anesthesia,significantly reduce the systolic blood pressure,diastolic blood pressure,and heart rate levels,and significantly reduce the adverse reactions of chills,high fever,nausea,vomiting,and agitation.The sedative effect is significantly improved,and the effective prognosis of patients with general anesthesia is fina
作者 朱明刚 ZHU Minggang(Department of Anesthesiology,Xintai Hospital Affiliated to Shandong First Medical University(Xintai People's Hospital),Tai'an,Shandong Province,271200 China)
出处 《中外医疗》 2021年第20期106-108,共3页 China & Foreign Medical Treatment
关键词 静脉注射 右美托咪定 全身麻醉 收缩压 舒张压 心率 不良反应 镇定评分 Intravenous injection Dexmedetomidine General anesthesia Systolic blood pressure Diastolic blood pressure Heart rate Adverse reactions Sedation score
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