摘要
目的比较不同病理类型肺癌患者的细胞角质蛋白19片段抗原21-1(CYFRA21-1)、胃泌素释放肽前体(ProGRP)、鳞状细胞癌抗原(SCC-Ag)、可溶性E-钙黏蛋白(SE-CAD)水平。方法选取2017年1月至2020年1月收治的100例肺癌患者设为肺癌组,同期选取100例肺部良性病变患者和100名健康体检者分别设为良性组和健康组。检测并比较各组的CYFRA21-1、ProGRP、SCC-Ag、SE-CAD水平。结果肺癌组的CYFRA21-1、ProGRP、SCC-Ag、SE-CAD水平均高于良性组和健康组,且良性组高于健康组,差异具有统计学意义(P<0.05)。非小细胞肺癌患者的CYFRA21-1、SCC-Ag水平均高于小细胞肺癌患者,ProGRP水平低于小细胞肺癌患者,差异具有统计学意义(P<0.05)。鳞癌患者的CYFRA21-1、SCC-Ag水平均高于腺癌患者,差异具有统计学意义(P<0.05)。结论肺癌患者的CYFRA21-1、ProGRP、SCC-Ag、SE-CAD水平明显升高,不同病理类型肺癌中CYFRA21-1、ProGRP、SCC-Ag呈不同程度的表达。
Objective To compare the levels of cytokeratin 19 fragment antigen 21-1(CYFRA21-1),pro-gastrin-releasing peptide(ProGRP),squamous cell carcinoma antigen(SCC-Ag),soluble E-cadherin(SE-CAD)in patients with different pathological types of lung cancer.Methods A total of 100 patients with lung cancer treated from January 2017 to January 2020 were selected as lung cancer group,100 patients with benign lung lesions and 100 healthy persons were selected as benign group and healthy group respectively.The levels of CYFRA21-1,ProGRP,SCC-Ag and SE-CAD in each group were detected and compared.Results The levels of CYFRA21-1,ProGRP,SCC-Ag,and SE-CAD in the lung cancer group were higher than those in the benign group and the healthy group,and those in the benign group were higher than the healthy group,and the differences were statistically significant(P<0.05).The levels of CYFRA21-1 and SCC-Ag in patients with non-small cell lung cancer were higher than those in patients with small cell lung cancer,and the level of ProGRP was lower than that in patients with small cell lung cancer,and the differences were statistically significant(P<0.05).The levels of CYFRA21-1 and SCC-Ag in patients with squamous cell carcinoma were higher than those in patients with adenocarcinoma,and the differences were statistically significant(P<0.05).Conclusion The levels of CYFRA21-1,ProGRP,SCC-Ag and SE-CAD were significantly increased in patients with lung cancer.CYFRA21-1,ProGRP and SCC-Ag were expressed in different pathological types of lung cancer.
作者
杨亚莉
YANG Yali(Pathology Department,Fufeng People's Hospital,Baoji 722200,China)
出处
《临床医学研究与实践》
2021年第26期56-58,共3页
Clinical Research and Practice
