摘要
目的:探究血清变应原sIgE及外周血嗜酸性粒细胞比例与慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)患者内镜手术后疗效的相关性。方法:选取2016年1月~2018年12月收治的行功能性内镜鼻窦手术的患者100例作为研究对象,统计血清变应原sIgE阳性患者的变应原种类;比较血清变应原sIgE阳性及阴性患者术前外周血EOS数目及比例;比较两组患者术后6个月的外周血EOS比例、VAS评分、SNOT-22评分、鼻窦CT评分及术腔Lund-Kennedy评分;计算患者外周血EOS比例与术后6个月的外周血EOS比例、VAS评分、SNOT-22评分、鼻窦CT评分及术腔Lund-Kennedy评分的相关性。结果:按照血清变应原sIgE的结果将患者分为变应原阳性组(46例)及变应原阴性组(54例),吸入性变应原:户尘螨29例,蟑螂10例,树木花粉8例,草花粉4例,屋尘3例;食物变应原:蟹5例,虾4例,芒果3例,牛肉1例;血清变应原sIgE阳性及阴性的CRSwNP患者术前外周血EOS计数及比例比较,差异无统计学意义(P>0.05);术后6个月,与阳性患者相比,阴性患者VAS评分、SNOT-22评分及术腔Lund-Kennedy评分均显著下降,差异有统计学意义(P<0.05),EOS比例及鼻窦CT评分比较,差异无统计学意义(P>0.05);CRSwNP患者外周血EOS比例与术后6个月的外周血EOS比例、VAS评分、SNOT-22评分、鼻窦CT评分及术腔Lund-Kennedy评分无相关性,差异无统计学意义(r=0.176,0.217,0.135,0.214,0.142,P>0.05)。结论:血清变应原阳性的CRSwNP患者术后疗效可能更差,需要在手术前及手术后采取积极措施进行脱敏反应,防治术后复发,提升疗效。而血清EOS比例与CRSwNP患者术后疗效可能不存在相关性,仍需要进一步探讨。
Objective To explore the correlation between serum allergen sIgE and peripheral blood eosinophil ratio and the efficacy of endoscopic surgery in patients with chronic rhinosinusitis with nasal polyps(CRSwNP).Method 100 patients with functional endoscopic sinus surgery admitted to our hospital from January 2016 to December 2018 were enrolled as the study subjects.The allergen types of serum allergen sIgE positive patients were counted.The number and proportion of EOS in preoperative peripheral blood were compared between the two groups of patients with sIgE positive and negative serum.Peripheral blood EOS ratio,VAS score,SNOT-22 score,sinus CT score and intraoperative Lund-Kennedy score were compared between the two groups at 6 months postoperatively.The correlation between EOS ratio of peripheral blood and the proportion of peripheral blood EOS,VAS score,SNOT-22 score,sinus CT score and Lund-Kennedy score of the operation were calculated.Results According to the results of serum allergen sIgE,the patients were divided into allergen-positive group(46 cases)and allergen-negative group(54 cases),inhalation allergen:29 cases of house dust mites,10 cases of sputum,8 cases of tree pollen,4 cases of grass pollen,3 cases of house dust;food allergen:5 cases of crab,4 cases of shrimp,3 cases of mango,1 case of beef.There was no significant difference in preoperative peripheral blood EOS counts and proportions between patients with serum allergen sIgE positive and negative CRSwNP(P>0.05).At 6 months after surgery,the VAS score,SNOT-22 score,and Lund-Kennedy score in the negative patients were significantly lower than those in the positive patients(P<0.05),and the EOS ratio and sinus CT scores were not statistically significant(P>0.05).There was no correlation between the proportion of EOS in peripheral blood of patients with CRSwNP and the proportion of peripheral blood EOS,VAS score,SNOT-22 score,sinus CT score and Lund-Kennedy score at6 months after operation(r=0.176,0.217,0.135,0.214,0.142,P>0.05).Conclusion The serum al
作者
吴文丽
王星
林荣封
白玉
张燕飞
WU Wen-li;WANG Xing;LIN Rong-feng(The Fifth Affiliated Hospital of Shenzhen University-Department of Otolaryngology,Bao'an District Central Hospital,Shenzhen 518000,China;Department of Radiology,Bao'an District Central Hospital,Shenzhen 518000,China)
出处
《吉林医学》
CAS
2021年第9期2115-2118,共4页
Jilin Medical Journal
