摘要
目的探讨重组人干扰素α2b联合孟鲁司特钠对小儿毛细支气管炎肺功能及血清促炎症因子水平的影响。方法按入院顺序选取2016年7月—2019年5月黄石市鄂东医疗集团市妇幼保健院新生儿科收治的毛细支气管炎患儿126例作为研究对象,采用随机数字表法分为对照组和观察组,对照组在常规治疗的基础上给予孟鲁司特钠治疗,观察组在对照组的基础上给予重组人干扰素α2b治疗,对比二组患儿临床症状和体征评分,肺功能指标,血清促炎症因子表达水平,同时记录临床症状体征消退时间和治疗效果。结果治疗1周后,二组患儿的临床症状和体征评分均显著下降(均P<0.001),且观察组在咳嗽、喘息和肺部啰音方面评分低于对照组,差异均有统计学意义(均P<0.05);观察组的肺功能指标(每kg体重潮气量、吸呼气时间比、呼吸阻力和到达潮气呼气峰值容积比)改善情况显著优于对照组,差异均有统计学意义(均P<0.05);同时二组患儿的血清促炎症细胞因子水平(白介素1-α,白介素-6,肿瘤坏死因子α)均在治疗后显著降低,且观察组低于对照组,差异均有统计学意义(均P<0.001);与对照组比较,观察组临床症状体征消失时间及住院时间明显缩短,差异均有统计学意义,且临床治愈率和总有效率也显著高于对照组,差异均有统计学意义(均P<0.05)。结论重组人干扰素α2b联合孟鲁司特钠可缓解毛细支气管炎患儿临床症状,改善患儿肺功能,降低血清促炎症因子水平,提高治疗效果,缩短住院时间。
Objective To investigate the effect of recombinant human interferon(rhIFN) α2 b combined with montelukast sodium on pulmonary function and serum proinflammatory factor levels in children with bronchiolitis.Methods According to the order of admission, one hundred and tweenty six children with bronchiolitis admitted to our hospital from July 2016 to may 2019 were selected as the research objects, and randomly divided into a control group and an observation group.The control group was treated with montelukast sodium on the basis of conventional treatment.The observation group was treated with rhIFN α2 b on the basis of the control group.The symptoms and signs scores, pulmonary function indicators, serum pro-inflammatory factor expression levels were compared between the two groups, and the clinical symptom resolution time and treatment effect were recorded.Results After one week of treatment, the clinical symptom scores and signs scoresof the two groups of children decreased significantly(P<0.001),and the observation group scored lower in cough, wheezing and lung rale than the control group, the difference is statistically significant(P< 0.05).And the improvement of lung function indicators(VT/kg, Ti/Te, VPTEF/VE,Rrs) in the observation group was significantly better than that in the control group, the difference is statistically significant(P< 0.05).Meanwhile, serum pro-inflammatory cytokine levels(IL1-α,IL-6,TNFα) in the two groups of children were significantly reduced after treatment, and the observation group was lower than the control group, the difference is statistically significant(P<0.001).Compared with the control group, the time ofdisappearance ofclinical symptoms and signs and the length of hospital stay in the observation group were significantly shortened, and the clinical cure rate and total effective rate were significantly higher than those in the control group, the difference is statistically significant(P< 0.05).Conclusion TherhIFN α2 b combined with montelukast sodium alleviated the clinica
作者
丁月银
程兰
王义乾
王兰香
雷菊芳
DING Yueyin;CHENG Lan;WANG Yiqian;WANG Lanxiang;LEI Jufang(Department of Neonatology,The Maternal and Child Health Hospital of Huangshi,Edong medical group,Huangshi 435000,China)
出处
《中国煤炭工业医学杂志》
2021年第3期288-292,共5页
Chinese Journal of Coal Industry Medicine
基金
湖北省卫生计生委基金项目(编号:WJ2017M210)。
