摘要
目的分析比较不同药物联合用药方案治疗小儿支气管炎的临床效果。方法研究中从我院2017年9月至2018年9月接诊的支气管炎患儿中选120例为试验对象。根据双盲分组方法将患儿分为观察组和对照组,均为60例。观察组患儿应用孟鲁司特钠联合酮替芬治疗,对照组患儿采用孟鲁司特钠联合喜炎平治疗,对比两组患儿临床治疗效率。结果(1)经过治疗观察组(57例,占95.00%)的整体有效率相对对照组(49例,占81.67%)更为理想,差异有统计学意义(P<0.05);(2)观察组(3例,占5.00%)治疗后不良反应的发生率比对照组(10例,占16.67%)更低,差异有统计学意义(P<0.05);(3)经过治疗,观察组的退热所需时间明显更短、憋喘缓解时比对照读短,咳嗽消失所需时间少于对照组,肺部啰音消失所需时间也少于对照组,差异有统计学意义(P<0.05);(4)治疗前,两组的PCT、TNF-α、TGF-β_(1)无差异(P>0.05),治疗后,观察组的改善效果更为理想,差异有统计学意义(P<0.05);(5)治疗前,两组在睡眠质量方面的差异不明显(P>0.05),治疗后,观察组的改善效果更为理想,差异有统计学意义(P<0.05);(6)观察组的满意度相比对照组而言更高,差异有统计学意义(P<0.05)。结论支气管患儿将孟鲁司特钠与酮替芬联合应用治疗效果更显著,可以提高整体治疗的有效率,减少不良反应,促进患儿临床症状的缓解,减轻患儿体内的炎性因子水平,改善整体睡眠质量,提高患儿家属的满意度,值得推荐。
Objective To analyze and compare the clinical effects of different drug combination regimens in the treatment of bronchitis in children.Methods In the study,120 children with bronchitis admitted from our hospital from September 2017 to September 2018 were selected as experimental subjects.According to the double-blind grouping method,the children were divided into observation group and control group,both of which were 60 cases.Children in the observation group were treated with montelukast sodium combined with ketotifen,and children in the control group were treated with montelukast sodium combined with xiyanping.The clinical treatment efficiency of children in each group was compared.Results(1)After treatment,the overall effective rate of the observation group(57 cases,accounting for 95.00%)was more ideal than that of the control group(49 cases,accounting for 81.67%),and the difference was statistically significant(P<0.05).(2)Observation the incidence of adverse reactions after treatment in the group(3 cases,accounting for 5.00%)was lower than that in the control group(10 cases,accounting for 16.67%),and the difference was statistically significant(P<0.05).(3)The antipyretic time was significantly shorter,the reading time when wheezing was relieved was shorter than that of the control group,the cough disappearance time was shorter than that of the control group,and the disappearance time of lung rales was also shorter than that of the control group,and the difference was statistically significant(P<0.05).(4)Before treatment,there was no difference in PCT,TNF-α,TGF-β_(1) between the two groups(P>0.05).After treatment,the improvement effect of the observation group was more ideal,and the difference was statistically significant(P<0.05).(5)Treatment Before treatment,there was no significant difference in sleep quality between the two groups(P>0.05).After treatment,the improvement effect of the observation group was more ideal,and the difference was statistically significant(P<0.05).(6)The satisfaction of the obse
作者
郭坤
GUO Kun(Fuxin No.2 People's Hospital of Liaoning Province(Fuxin maternity Hospital),Fuxin 123000,China)
出处
《中国医药指南》
2022年第7期50-53,共4页
Guide of China Medicine
关键词
药物联用
小儿支气管炎
孟鲁司特钠
酮替芬
喜炎平
Drug Combination
Pediatric Bronchitis
Montelukast Sodium
Ketotifen
Xiyanping
