摘要
目的探讨肥胖型非酒精性脂肪性肝病(NAFLD)患者血浆中促酰基化蛋白(ASP)与肥胖症的相关性。方法研究对象选取2017年至2019年如东县人民医院治疗的各72例肥胖型和非肥胖型NAFLD患者,以及60例同期本院体检合格的健康人。分别比较三组研究对象血清或血浆中的生化指标,并用Pearson分析NAFLD患者血浆中ASP与体质指数(BMI)的相关性。结果与对照组相比,肥胖型与非肥胖型NAFLD患者血浆ASP等糖脂代谢含量显著增加(P<0.01),而与非肥胖型NAFLD组相比,肥胖型NAFLD患者ASP等糖脂代谢指标增加程度更显著(P<0.01)。结论肥胖型NAFLD患者血浆中ASP含量较高,可能与肥胖及血液中的脂代谢有关。
Objective To investigate the relationship between plasma acylation stimulating protein(ASP)and obesity in obese patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 72 obese and non-obese NAFLD patients in our hospital from 2017 to 2019 were selected as the research objects,and 60 healthy people who passed the physical examination in the same period in our hospital were selected.The serum or plasma biochemical indexes of the three groups were compared,and the correlation between ASP and body mass index(BMI)in NAFLD patients was analyzed by Pearson.Results Compared with the control group,the levels of plasma ASP and other glucose and lipid metabolism in obese and non-obese NAFLD patients were significantly increased(P<0.01),while compared with non-obese NAFLD group,the level of ASP and other glycolipid metabolism indexes in obese NAFLD patients increased more significantly(P<0.01).Conclusion The content of ASP in plasma of obese NAFLD patients is higher,which may be related to obesity and blood lipid metabolism.
作者
李小祥
顾小丹
许卫东
LI Xiao-xiang;GU Xiao-dan;XU Wei-dong(Department of Gastroenterology,Rudong people's Hospital,Rudong,Jiangsu 226400,China)
出处
《肝脏》
2021年第8期913-916,共4页
Chinese Hepatology
基金
南通市市级科技计划项目(MSZ18206)。
关键词
肥胖型非酒精性脂肪性肝病
血浆促酰基化蛋白
脂代谢
Obese nonalcoholic fatty liver disease
Plasma acylation promoting protein
Lipid metabolism
