摘要
皮肤作为人体最大的器官,有着屏障功能、免疫应答、防止水分流失和排泄废物等重要作用。大面积的严重皮肤损伤患者会由于缺乏充足的可移植皮肤而死亡。生物3D打印技术的发展为可移植皮肤的制造提供了解决办法。生物3D打印技术可以定制化制造功能性的皮肤替代品,有望解决移植皮肤短缺的困难。本文简述了皮肤创伤修复原理,比较了用于皮肤修复的生物材料墨水、细胞和主要的生物3D打印技术,分析了光电技术在3D打印皮肤上的应用潜力,并总结了生物3D打印技术在皮肤修复应用中所面临的挑战和未来的发展方向,提出了光电技术在生物3D打印中的应用需求。
The skin is the largest organ of the human body,which plays an important role in barrier function,immune response,preventing water loss and excreting waste.Patients with large-scale severe skin injuries will die due to lack of adequate skin grafts.The development of 3D bioprinting technology provides a solution for the manufacture of transplantable skin.Firstly,the principles of skin wound repairing are described.Secondly,the bioinks,cells and main 3D bioprinting technologies used in skin wound repairing are compared.Then,the opto-electronic technologies involved are analyzed,and the challenges and future development of 3D bioprinting in the application of skin repair are summarized.Finally,the application requirements of opto-electronic technology in 3D bioprinting are proposed.
作者
连伟龙
连芩
焦天
何晓宁
赵明
胡大海
万敏
Lian Weilong;Lian Qin;Jiao Tian;He Xiaoning;Zhao Ming;Hu Dahai;Wan Min(State Key Laboratory for Manufacturing System Engineering,School of Mechanical Engineering,Xi’an Jiaotong University,Xi’an,Shaanxi 710054,China;Jihua Laboratory,Foshan,Guangdong 528200,China;NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices,Xi’an,Shaanxi 710054,China;Xidian University,Xi’an,Shaanxi 710049,China;Department of Burns and Cutaneous Surgery,Xijing Hospital,Air Force Medical University,Xi’an,Shaanxi 710032,China;Shandong Quality Inspection Center for Medical Devices,NMPA Key Laboratory for Quality Evaluation of Medical and Health Materials and Biological Protective Devices,Jinan,Shandong 250101,China)
出处
《光电工程》
CAS
CSCD
北大核心
2021年第8期1-18,共18页
Opto-Electronic Engineering
基金
工信部增材制造专项(2018YFE0207900)
中国人民解放军科技计划(BWS17J036)
季华实验室建设项目(X200031TM200)
国家自然科学基金项目(51835010,51375371)。
