摘要
目的:观察杠杆定位手法结合脉冲电场对腰椎间盘突出症患者的镇痛效应及血清中白细胞介素-1β(interleukin-1β,IL-1β),肿瘤坏死因子(tumor necrosis factor-α,TNF-α)影响。方法:2018年1月至2019年3月纳入58例腰椎间盘突出症患者进行研究,将58例患者用数字表法随机分为观察组和对照组。观察组29例,其中男16例,女13例,年龄(38.03±11.29)岁,采用杠杆定位手法结合脉冲电场治疗。对照组29例,其中男17例,女12例,年龄(38.21±9.16)岁,采用脉冲电场治疗。两组患者每周均治疗3次,隔1 d治疗1次,3次为1个疗程,治疗2个疗程后,采用疼痛数字评分法(numeric rating scales,NRS)对两组患者治疗前后进行评分;同时对治疗前后血清中IL-1β和TNF-α浓度进行测量。结果:观察组和对照组治疗前NRS评分分别是4.21±1.76,4.66±1.61,治疗后分别为1.28±0.84,2.10±1.35,治疗后观察组NRS评分明显低于对照组(P<0.05)。治疗后两组患者的IL-1β和TNF-α浓度均有变低(P<0.05),观察组和对照组治疗前IL-1β分别为(119.01±69.65)、(112.23±78.43)pg/ml,治疗后分别为(59.78±36.60)、(77.51±40.46)pg/ml;观察组和对照组治疗前TNF-α分别为(1.68±1.13)、(1.74±0.70)pg/ml,治疗后分别为(1.14±0.56)、(1.45±0.58)pg/ml,观察组IL-1β、TNF-α变化均优于对照组(P<0.05)。结论:杠杆定位手法结合脉冲电场对腰椎间盘突出症患者有较好的镇痛效应,并对腰椎间盘突出症患者的血清IL-1β和TNF-α浓度有明显影响,可作为指导临床的依据,但杠杆定位手法结合脉冲电场的协同作用及对临床治疗的指南还需要进一步研究。
Objective:To observe the analgesic effect of lever positioning manipulation combined with pulsed electric field on patients with lumbar disc herniation and the influence on serum IL-1βand TNF-α.Methods:From January 2018 to March 2019,58 patients with lumbar disc herniation were included in the study,which were randomly divided into observation group and control group by digital table method.Observation group of 29 cases,including 16 males and 13 females,aged(38.03±11.29)years old,were treated with lever positioning manipulation combined with pulsed electric field.The 29 cases in control group,including 17 males and 12 females,aged(38.21±9.16)years old,were treated with pulsed electric field.Both groups of patients were treated 3 times a week,once every other day,3 times as a course of treatment.After 2 courses of treatment,the two groups of patients were scored before and after treatment by the numeric rating scales(NRS);at the same time,the serum levels of IL-1βand TNF-αwere measured before and after treatment.Results:The NRS scores of observation group and control group were 4.21±1.76,4.66±1.61 before treatment,and 1.28±0.84,2.10±1.35 after treatment,respectively.The NRS scores of the observation group after treatment was significantly lower than that of the control group(P<0.05).After treatment,the concentrations of IL-1βand TNF-αin both groups became lower(P<0.05).The levels of IL-1βin observation group and control group before treatment were(119.01±69.65),(112.23±78.43)pg/ml,and after treatment were(59.78±36.60),(77.51±40.46)pg/ml,respectively.The levels of TNF-αin observation group and control group before treatment were(1.68±1.13),(1.74±0.70)pg/ml,and after treatment were(1.14±0.56),(1.45±0.58)pg/ml,respectively.The change of IL-1βand TNF-αin observation group was better than that in control group(P<0.05).Conclusion:The lever positioning manipulation combined with pulsed electric field has a good analgesic effect on patients with lumbar disc herniation,and it has a significant impac
作者
吕立江
毛凌宇
李景虎
杨超
王玮娃
王晟
刘鼎
LYU Li-jiang;MAO Ling-yu;LI Jing-hu;YANG Chao;WANG Wei-wa;WANG Sheng;LIU Ding(The Third Clinical Medical College of Zhejiang University of Traditional Chinese Medicine,Hangzhou310053,Zhejiang,China)
出处
《中国骨伤》
CAS
CSCD
2021年第8期780-784,共5页
China Journal of Orthopaedics and Traumatology
基金
国家自然科学基金项目(编号:81273866,81774442)
国家临床重点专科建设项目-推拿科[编号:国卫医发(2013)42]
浙江省重大疾病中医药防治中心项目(编号:浙中医药2018-9)。
关键词
腰椎
椎间盘移位
手法
骨科
脉冲电场
镇痛
白细胞介素-1Β
肿瘤坏死因子-Α
Lumbar vertebrae
Intervertebral disc displacement
Manipulation,Orthopedic
Pulsed electric field
Analgesia
Interleukin-1β
Tumor necrosis factor-α
